Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2C | Q5R387 | 1/20 | 0.37 |
| ▸ | CES1 | P23141 | 9/20 | 0.37 |
| ▸ | FAAH | O00519 | 8/20 | 0.35 |
| ▸ | CES2 | O00748 | 4/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | BMP1 | P13497 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14229464 | 0.97 | PLA2G2C (0.35) | PLA2G2CCES1FAAHCES2CYP2C9 | |
| SCHEMBL14229150 | 0.93 | PLA2G2C (0.33) | PLA2G2CCES1FAAHCES2CYP2C9 | |
| SCHEMBL14200391 | 0.92 | PLA2G2C (0.33) | PLA2G2CCES1FAAHCES2 | |
| SCHEMBL14230127 | 0.89 | PLA2G2C (0.35) | PLA2G2CCES1FAAHCES2CYP2C9 | |
| SCHEMBL14229193 | 0.88 | CES1 (0.38) | CES1FAAHCES2BMP1 | |
| SCHEMBL14229521 | 0.85 | CES1 (0.36) | CES1FAAHCES2 | |
| SCHEMBL14229192 | 0.83 | PLA2G2C (0.35) | PLA2G2CCES1CYP2C9TSHRCYP2C19 | |
| SCHEMBL14200407 | 0.82 | CA1 (0.32) | — | |
| SCHEMBL14230124 | 0.82 | CES1 (0.34) | CES1FAAHCES2 | |
| SCHEMBL14200401 | 0.81 | CES1 (0.33) | CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7365093-B2 | Endothelin antagonists | ABBOTT LABORATORIES (US) | 2008-04-29 | — | — | US | disclosed |
| US-7208517-B1 | Endothelin antagonists | ABBOTT LABORTORIES (US) | 2007-04-24 | — | — | US | disclosed |