Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2C | Q5R387 | 1/20 | 0.35 |
| ▸ | CES1 | P23141 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14228927 | 0.89 | CES1 (0.33) | CES1 | |
| SCHEMBL14229459 | 0.83 | PLA2G2C (0.37) | PLA2G2CCES1CYP2C9TSHRCYP2C19 | |
| SCHEMBL14200405 | 0.82 | — | — | |
| SCHEMBL14230127 | 0.82 | PLA2G2C (0.35) | PLA2G2CCES1CYP2C9TSHRCYP2C19 | |
| SCHEMBL14229464 | 0.81 | PLA2G2C (0.35) | PLA2G2CCES1CYP2C9TSHRCYP2C19 | |
| SCHEMBL14229190 | 0.80 | CES1 (0.33) | CES1 | |
| SCHEMBL14229150 | 0.77 | PLA2G2C (0.33) | PLA2G2CCES1CYP2C9TSHRCYP2C19 | |
| SCHEMBL14200391 | 0.76 | PLA2G2C (0.33) | PLA2G2CCES1 | |
| SCHEMBL14229116 | 0.75 | TP53 (0.35) | HSD17B10 | |
| SCHEMBL14229376 | 0.73 | CA2 (0.41) | CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7365093-B2 | Endothelin antagonists | ABBOTT LABORATORIES (US) | 2008-04-29 | — | — | US | disclosed |
| US-7208517-B1 | Endothelin antagonists | ABBOTT LABORTORIES (US) | 2007-04-24 | — | — | US | disclosed |