Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14229116 | 0.86 | TP53 (0.35) | TP53CA2TDP1 | |
| SCHEMBL14229376 | 0.84 | CA2 (0.41) | TP53CA2 | |
| SCHEMBL14228925 | 0.82 | TP53 (0.38) | TP53CA2 | |
| SCHEMBL14229194 | 0.82 | CA2 (0.44) | TP53CA2 | |
| SCHEMBL14229117 | 0.80 | TDP1 (0.32) | TP53TDP1 | |
| SCHEMBL14229375 | 0.79 | CA1 (0.40) | TP53CA2 | |
| SCHEMBL14229680 | 0.79 | TSHR (0.36) | CA2TDP1 | |
| SCHEMBL14230126 | 0.79 | TP53 (0.36) | TP53CA2 | |
| SCHEMBL14229190 | 0.77 | CES1 (0.33) | — | |
| SCHEMBL14200406 | 0.76 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7365093-B2 | Endothelin antagonists | ABBOTT LABORATORIES (US) | 2008-04-29 | — | — | US | disclosed |
| US-7208517-B1 | Endothelin antagonists | ABBOTT LABORTORIES (US) | 2007-04-24 | — | — | US | disclosed |