Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.53 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.53 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.53 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.53 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.53 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.53 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | THRA | P10827 | 1/20 | 0.52 |
| ▸ | THRB | P10828 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | F2R | P25116 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14229579 | 0.94 | MAPK1 (0.55) | MAPK1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL14229285 | 0.92 | MAPK1 (0.54) | MAPK1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL14228994 | 0.91 | MAPK1 (0.53) | MAPK1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL14229423 | 0.90 | MAPK1 (0.51) | MAPK1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL14229427 | 0.88 | CETP (0.50) | MAPK1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL14229904 | 0.87 | MAPK1 (0.55) | MAPK1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL21600596 | 0.86 | HPGD (0.48) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL14229246 | 0.85 | MAPK1 (0.57) | MAPK1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL7750852 | 0.84 | HDAC3 (0.71) | MAPK1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL14229077 | 0.83 | MAPK1 (0.51) | MAPK1HDAC3HDAC4HDAC1HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7365093-B2 | Endothelin antagonists | ABBOTT LABORATORIES (US) | 2008-04-29 | — | — | US | disclosed |
| US-7208517-B1 | Endothelin antagonists | ABBOTT LABORTORIES (US) | 2007-04-24 | — | — | US | disclosed |