SCHEMBL21600596

SCHEMBL21600596

CCC(=O)Nc1cccc(CC)c1CC

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HPGD P15428 2/20 0.48
MAPT P10636 2/20 0.48
HDAC3 O15379 1/20 0.47
HDAC4 P56524 1/20 0.47
HDAC1 Q13547 1/20 0.47
HDAC7 Q8WUI4 1/20 0.47
HDAC2 Q92769 1/20 0.47
HDAC10 Q969S8 1/20 0.47
HDAC11 Q96DB2 1/20 0.47
HDAC8 Q9BY41 1/20 0.47
HDAC6 Q9UBN7 1/20 0.47
HDAC9 Q9UKV0 1/20 0.47
HDAC5 Q9UQL6 1/20 0.47
ALDH1A1 P00352 3/20 0.45
RAB9A P51151 2/20 0.45
NPC1 O15118 1/20 0.45
SMN1; SMN2 Q16637 1/20 0.45
POLB P06746 2/20 0.45
NR4A1 P22736 1/20 0.45
GAA P10253 2/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12408064 0.91 MAPT (0.51) HPGDMAPTHDAC3HDAC4HDAC1
SCHEMBL14229477 0.86 MAPK1 (0.58) HPGDMAPTHDAC3HDAC4HDAC1
SCHEMBL15093896 0.85 HTT (0.53) MAPTALDH1A1SMN1; SMN2POLBGAA
SCHEMBL2018495 0.85 CLCN2 (0.47) MAPTHDAC3HDAC4HDAC1HDAC7
SCHEMBL29580700 0.85 HTT (0.53) MAPTALDH1A1SMN1; SMN2POLBGAA
SCHEMBL3940043 0.84 MAPK1 (0.50) HPGDALDH1A1RAB9ANPC1SMN1; SMN2
SCHEMBL14201058 0.83 SMN1; SMN2 (0.58) HPGDMAPTHDAC3HDAC4HDAC1
SCHEMBL3022920 0.83 HDAC3 (0.65) MAPTHDAC3HDAC4HDAC1HDAC7
SCHEMBL1720103 0.82 GAA (0.49) MAPTHDAC3HDAC4HDAC1HDAC7
SCHEMBL11656679 0.81 ALDH1A1 (0.45) HPGDMAPTHDAC3HDAC4HDAC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3202766-B1 ISOXAZOLE DERIVATIVE AS MUTATED ISOCITRATE DEHYDROGENASE 1 INHIBITOR DAIICHI SANKYO CO LTD (JP) 2019-12-25 EP disclosed