Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 3/20 | 0.59 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.59 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.46 |
| ▸ | TYR | P14679 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.38 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.38 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.38 |
| ▸ | KIF11 | P52732 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
| ▸ | USP5 | P45974 | 1/20 | 0.36 |
| ▸ | MGLL | Q99685 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL565578 | 0.82 | CYP2C9 (0.57) | CYP2C9HIF1ACYP2D6PTPN5TYR | |
| Hydrogen Peroxide SCHEMBL28402319 | 0.80 | CYP2C9 (0.61) | CYP2C9HIF1ACYP2D6PTPN5TYR | |
| Hydrogen Peroxide SCHEMBL2387288 | 0.77 | CYP2C9 (0.57) | CYP2C9HIF1ACYP2D6PTPN5TYR | |
| Hydrogen Peroxide SCHEMBL28795529 | 0.77 | CYP2C9 (0.57) | CYP2C9HIF1ACYP2D6PTPN5TYR | |
| SCHEMBL23134920 | 0.77 | ALDH1A1 (0.46) | CYP2C9HIF1ACYP2D6MEN1KMT2A | |
| SCHEMBL20085463 | 0.77 | CYP2D6 (0.52) | CYP2C9HIF1ACYP2D6PTPN5TYR | |
| SCHEMBL13324724 | 0.77 | NR1H2 (0.56) | CYP2C9HIF1ACYP2D6PTPN5HTT | |
| SCHEMBL9175432 | 0.77 | PTPN5 (0.53) | CYP2C9HIF1ACYP2D6PTPN5TYR | |
| SCHEMBL28555994 | 0.77 | CYP2C9 (0.52) | CYP2C9HIF1ACYP2D6PTPN5TYR | |
| Hydrogen Peroxide SCHEMBL20915049 | 0.76 | TYR (0.55) | CYP2C9HIF1ACYP2D6TYRHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008041053-A2 | INHIBITORS OF VEGF RECEPTOR AND HGF RECEPTOR SIGNALING | METHYLGENE, INC. (CA) | 2008-04-10 | — | — | WO | disclosed |