Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.53 |
| ▸ | MEN1 | O00255 | 5/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | NAMPT | P43490 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lithium SCHEMBL385059 | 0.99 | KDM4E (0.56) | KDM4EKMT2AMEN1ALDH1A1TDP1 | |
| SCHEMBL385057 | 0.99 | KDM4E (0.56) | KDM4EKMT2AMEN1ALDH1A1TDP1 | |
| SCHEMBL383102 | 0.89 | KDM4E (0.56) | KDM4EKMT2AMEN1ALDH1A1TDP1 | |
| Lithium Ion SCHEMBL385058 | 0.88 | KDM4E (0.55) | KDM4EKMT2AMEN1ALDH1A1TDP1 | |
| SCHEMBL5506172 | 0.87 | KDM4E (0.48) | KDM4EKMT2AMEN1ALDH1A1TDP1 | |
| SCHEMBL17835591 | 0.85 | KDM4E (0.55) | KDM4EKMT2AMEN1ALDH1A1TDP1 | |
| SCHEMBL382555 | 0.83 | L3MBTL1 (0.53) | KDM4EKMT2AMEN1ALDH1A1TDP1 | |
| SCHEMBL12855318 | 0.81 | KDM4E (0.63) | KDM4EKMT2AMEN1ALDH1A1TDP1 | |
| SCHEMBL10268440 | 0.80 | KDM4E (0.58) | KDM4EKMT2AMEN1ALDH1A1TDP1 | |
| SCHEMBL10269550 | 0.80 | KDM4E (0.58) | KDM4EKMT2AMEN1ALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008044045-A1 | PHARMACEUTICAL COMBINATIONS | ASTEX THERAPEUTICS LIMITED (GB) | 2008-04-17 | — | — | WO | disclosed |