Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 10/20 | 0.48 |
| ▸ | LGALS3 | P17931 | 1/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.47 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.46 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28791816 | 0.87 | GPBAR1 (0.49) | PDE10ACYSLTR2CYSLTR1 | |
| SCHEMBL1423588 | 0.82 | PDE10A (0.52) | PDE10ALGALS3PDE4DCYSLTR2CYSLTR1 | |
| SCHEMBL27816170 | 0.81 | PDE10A (0.48) | PDE10ALGALS3PDE4DCYSLTR2CYSLTR1 | |
| SCHEMBL1423901 | 0.77 | PDE10A (0.62) | PDE10ALGALS3PDE4DCYSLTR2CYSLTR1 | |
| SCHEMBL1423737 | 0.77 | PDE10A (0.62) | PDE10ALGALS3PDE4DCYSLTR2CYSLTR1 | |
| SCHEMBL10663836 | 0.76 | CYSLTR1 (0.56) | PDE10ACYSLTR2CYSLTR1 | |
| SCHEMBL1423701 | 0.76 | PDE10A (0.60) | PDE10ALGALS3PDE4DCYSLTR2CYSLTR1 | |
| SCHEMBL1423576 | 0.76 | PDE10A (0.60) | PDE10ALGALS3PDE4DCYSLTR2CYSLTR1 | |
| SCHEMBL1423926 | 0.76 | PDE10A (0.64) | PDE10ALGALS3PDE4D | |
| SCHEMBL9447109 | 0.75 | CYSLTR1 (0.49) | PDE10ACYSLTR2CYSLTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102131798-A | Di-substituted phenyl compounds used as inhibitors of phosphodiesterase 10 | ENVIVO PHARMACEUTICALS INC | 2011-07-20 | — | — | CN | disclosed |
| EP-2297131-A2 | DI-SUBSTITUTED PHENYL COMPOUNDS AS PHOSPHODIESTERASE 10 INHIBITORS | Envivo Pharmaceuticals, Inc. (US) | 2011-03-23 | — | — | EP | disclosed |
| WO-2009158467-A2 | DI-SUBSTITUTED PHENYL COMPOUNDS | ENVIVO PHARMACEUTICALS, INC. (US) | 2009-12-30 | — | — | WO | disclosed |