Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.61 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.61 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 6/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | HPGD | P15428 | 4/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25323 | 0.85 | MEN1 (0.60) | KDM4EMEN1KMT2AALDH1A1HPGD | |
| SCHEMBL19417179 | 0.81 | MEN1 (0.56) | KDM4EMEN1KMT2AALDH1A1HPGD | |
| SCHEMBL10076067 | 0.81 | MEN1 (0.74) | KDM4EHSP90AA1HSP90AB1MEN1KMT2A | |
| SCHEMBL413907 | 0.79 | MEN1 (0.79) | KDM4EHSP90AA1HSP90AB1MEN1KMT2A | |
| SCHEMBL423874 | 0.79 | KDM4E (0.66) | KDM4EHSP90AA1HSP90AB1MEN1KMT2A | |
| SCHEMBL18544154 | 0.79 | MIF (0.53) | KDM4EHSP90AA1HSP90AB1MEN1KMT2A | |
| SCHEMBL7381830 | 0.76 | MEN1 (0.73) | KDM4EHSP90AA1HSP90AB1MEN1KMT2A | |
| SCHEMBL17412405 | 0.76 | KDM4E (0.61) | KDM4EHSP90AA1HSP90AB1MEN1KMT2A | |
| SCHEMBL602093 | 0.76 | KDM4E (0.61) | KDM4EHSP90AA1HSP90AB1MEN1KMT2A | |
| SCHEMBL21310211 | 0.76 | MEN1 (0.50) | KDM4EMEN1KMT2AALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2532667-A1 | Deazapurines useful as inhibitors of janus kinases | Vertex Pharmaceuticals Incorporated (US) | 2012-12-12 | — | — | EP | disclosed |