SCHEMBL423874

SCHEMBL423874

Clc1cc(-c2ccccc2)nc(-c2ccccc2)n1

nearest known ligand 0.66

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 4/20 0.66
LMNA P02545 3/20 0.66
HSP90AA1 P07900 1/20 0.66
HSP90AB1 P08238 1/20 0.66
MEN1 O00255 9/20 0.59
KMT2A Q03164 9/20 0.59
ALDH1A1 P00352 5/20 0.59
HPGD P15428 5/20 0.59
L3MBTL1 Q9Y468 3/20 0.59
SMN1; SMN2 Q16637 1/20 0.59
ADORA2A P29274 2/20 0.59
ADORA1 P30542 2/20 0.59
MAPT P10636 5/20 0.57
NTSR1 P30989 1/20 0.57
ATP4A P20648 1/20 0.54
ATP4B P51164 1/20 0.54
POLB P06746 1/20 0.53
CTDSP1 Q9GZU7 1/20 0.53
TDP1 Q9NUW8 2/20 0.52
MAPK1 P28482 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29518902 0.96 KDM4E (0.61) KDM4ELMNAHSP90AA1HSP90AB1MEN1
SCHEMBL17412180 0.96 KDM4E (0.61) KDM4ELMNAHSP90AA1HSP90AB1MEN1
SCHEMBL17412405 0.96 KDM4E (0.61) KDM4ELMNAHSP90AA1HSP90AB1MEN1
SCHEMBL17412407 0.96 KDM4E (0.61) KDM4ELMNAHSP90AA1HSP90AB1MEN1
SCHEMBL6504250 0.92 CTRC (0.58) KDM4ELMNAHSP90AA1HSP90AB1MEN1
SCHEMBL38654829 0.92 CTRC (0.58) KDM4ELMNAHSP90AA1HSP90AB1MEN1
SCHEMBL22225596 0.91 KDM4E (0.56) KDM4ELMNAHSP90AA1HSP90AB1MEN1
SCHEMBL22376054 0.90 KDM4E (0.59) KDM4ELMNAHSP90AA1HSP90AB1MEN1
SCHEMBL17412388 0.90 LMNA (0.59) KDM4ELMNAHSP90AA1HSP90AB1MEN1
SCHEMBL29450767 0.90 LMNA (0.59) KDM4ELMNAHSP90AA1HSP90AB1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 825 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20060084645-A1 Novel pyrimidine compounds, process for their preparation and compositions containing them DR. REDDY'S LABORATORIES LTD. (IN) 2006-04-20 US claimed
WO-2026101205-A1 ORGANIC LIGHT-EMITTING COMPOUND AND ORGANIC ELECTROLUMINESCENT DEVICE USING SAME 솔루스첨단소재 주식회사 2026-05-15 WO disclosed
WO-2026101206-A1 ORGANIC LIGHT-EMITTING COMPOUND AND ORGANIC ELECTROLUMINESCENT DEVICE USING SAME 솔루스첨단소재 주식회사 2026-05-15 WO disclosed
CN-122029252-A Organic light-emitting compound and organic electroluminescent device comprising the same 索路思高新材料有限公司 2026-05-12 CN disclosed
EP-4600325-B1 ORGANIC LIGHT-EMITTING COMPOUND, AND ORGANIC ELECTROLUMINESCENT DEVICE COMPRISING SAME SOLUS ADVANCED MATERIALS CO LTD (KR) 2026-04-29 EP disclosed
EP-4692276-A2 ORGANIC MOLECULES WITH A TRIFLUOROMETHYL-BIPHENYL CORE FOR USE IN OPTOELECTRONIC DEVICES Samsung Display Co., Ltd. (KR) 2026-02-11 EP disclosed
EP-3724181-B1 ORGANIC MOLECULES WITH A TRIFLUOROMETHYL-BIPHENYL CORE FOR USE IN OPTOELECTRONIC DEVICES SAMSUNG DISPLAY CO LTD (KR) 2026-01-28 EP disclosed
US-12532601-B2 Organic compound and organic electroluminescent device comprising same SOLUS ADVANCED MATERIALS CO., LTD. (KR) 2026-01-20 US disclosed
EP-4046992-B1 NITRILE SUBSTITUTED AND SPIRO-CONDENSED FLUORENES AND ORGANIC ELECTROLUMINESCENT DEVICE COMPRISING SAME SOLUS ADVANCED MATERIALS CO LTD (KR) 2025-12-17 EP disclosed
US-20250361207-A1 ORGANIC MOLECULES FOR USE IN OPTOELECTRONIC DEVICES SAMSUNG DISPLAY CO LTD (KR) 2025-11-27 US disclosed
US-20070032510-A1 Substituted pyrimidines as ligands of adenosine receptors UNIVERSITEIT LEIDEN (NL) 2007-02-08 US disclosed
EP-1667985-A1 SUBSTITUTED PYRIMIDINES AS LIGANDS OF ADENOSINE RECEPTORS Universiteit Leiden (NL) 2006-06-14 EP disclosed
US-20060094767-A1 2,3-Dihydro-6-nitroimidazo[2,1-b]oxazoles OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2006-05-04 US disclosed
US-20060084645-A1 Novel pyrimidine compounds, process for their preparation and compositions containing them DR. REDDY'S LABORATORIES LTD. (IN) 2006-04-20 US disclosed
WO-2006034473-A2 NOVEL PYRIMIDINE COMPOUNDS, PROCESS FOR THEIR PREPARATION AND COMPOSITIONS CONTAINING THEM REDDY US THERAPEUTICS, INC. (US) 2006-03-30 WO disclosed
EP-1555267-A1 2,3-DIHYDRO-6-NITROIMIDAZO 2,1-b OXAZOLES OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2005-07-20 EP disclosed
WO-2005033084-A1 SUBSTITUTED PYRIMIDINES AS LIGANDS OF ADENOSINE RECEPTORS UNIVERSITEIT LEIDEN (NL) 2005-04-14 WO disclosed
EP-0826673-B1 ACETAMIDE DERIVATIVES, PROCESS FOR PRODUCING THE SAME, AND MEDICINAL COMPOSITION CONTAINING THE SAME DAINIPPON PHARMACEUTICAL CO (JP) 2002-11-20 EP disclosed
US-5972946-A NERVOUS SYSTEM DISORDERS; PSYCHOLOGICAL DISORDERS DAINIPPON PHARMACEUTICAL CO., LTD. (JP) 1999-10-26 US disclosed
EP-0826673-A1 ACETAMIDE DERIVATIVES, PROCESS FOR PRODUCING THE SAME, AND MEDICINAL COMPOSITION CONTAINING THE SAME DAINIPPON PHARMACEUTICAL CO., LTD. (JP) 1998-03-04 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060084645-A1 Novel pyrimidine compounds, process for their preparation and compositions containing them UMPS, DPYD, TYMS KDM4E 3484/4885LMNA 704/4885HSP90AA1 3866/4885
US-20060094767-A1 2,3-Dihydro-6-nitroimidazo[2,1-b]oxazoles NR2C2, NR4A3, NR4A2 KDM4E 4854/4885LMNA 4152/4885HSP90AA1 2426/4885
US-20070032510-A1 Substituted pyrimidines as ligands of adenosine receptors ADORA2A, ADORA3, ADORA1 KDM4E 4307/4885LMNA 4202/4885HSP90AA1 2749/4885
US-12532601-B2 Organic compound and organic electroluminescent device comprising same TRPC6, TRPC1, KCNN1 KDM4E 3378/4885LMNA 401/4885HSP90AA1 2715/4885
US-20250361207-A1 ORGANIC MOLECULES FOR USE IN OPTOELECTRONIC DEVICES OR10J3, NR2E3, ORC3 KDM4E 2599/4885LMNA 4113/4885HSP90AA1 4815/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.