Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.60 |
| ▸ | CA12 | O43570 | 1/20 | 0.59 |
| ▸ | CA1 | P00915 | 1/20 | 0.59 |
| ▸ | CA2 | P00918 | 1/20 | 0.59 |
| ▸ | CA9 | Q16790 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | HTR1A | P08908 | 1/20 | 0.55 |
| ▸ | MAOA | P21397 | 1/20 | 0.55 |
| ▸ | MAOB | P27338 | 1/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.55 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30522606 | 0.88 | TDP1 (0.75) | TDP1CA12CA1CA2CA9 | |
| SCHEMBL3897267 | 0.88 | SMN1; SMN2 (0.60) | TDP1CA12CA1CA2CA9 | |
| SCHEMBL13194971 | 0.86 | TDP1 (0.58) | TDP1CA12CA1CA2CA9 | |
| SCHEMBL166433 | 0.86 | TDP1 (0.58) | TDP1CA12CA1CA2CA9 | |
| SCHEMBL1461242 | 0.84 | GAA (0.60) | TDP1CA12CA1CA2CA9 | |
| SCHEMBL427558 | 0.84 | TDP1 (0.57) | TDP1CA12CA1CA2CA9 | |
| SCHEMBL33262 | 0.84 | TDP1 (0.61) | TDP1CA12CA1CA2CA9 | |
| Hydrochloric Acid SCHEMBL5657522 | 0.84 | GLA (0.58) | TDP1CA12CA1CA2CA9 | |
| SCHEMBL23929061 | 0.82 | SMN1; SMN2 (0.82) | TDP1CA12CA1CA2CA9 | |
| SCHEMBL3464764 | 0.82 | SMN1; SMN2 (0.59) | TDP1CA12CA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2254889-B1 | PROTEIN KINASE INHIBITORS AND USE THEREOF | MERCK PATENT GMBH (DE) | 2012-12-19 | — | — | EP | claimed |