Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 1/20 | 0.48 |
| ▸ | PARP1 | P09874 | 3/20 | 0.47 |
| ▸ | MAP2 | P11137 | 1/20 | 0.41 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.40 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.40 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.40 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.40 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.40 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.40 |
| ▸ | CDC25B | P30305 | 1/20 | 0.40 |
| ▸ | UBE2I | P63279 | 1/20 | 0.40 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.40 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.40 |
| ▸ | DAO | P14920 | 1/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14237126 | 0.88 | PARP1 (0.62) | CSF1RPARP1MAP2GRIN2DGRIN3B | |
| SCHEMBL14237089 | 0.82 | KDM4E (0.45) | CSF1RPARP1GRIN2DGRIN3BGRIN1 | |
| SCHEMBL3454670 | 0.81 | PARP1 (0.57) | CSF1RPARP1MAP2GRIN2DGRIN3B | |
| SCHEMBL15884007 | 0.81 | ACHE (0.50) | CSF1RMAP2 | |
| SCHEMBL14828969 | 0.73 | KDM4E (0.45) | CSF1RPARP1MAP2GRIN2DGRIN3B | |
| SCHEMBL20792931 | 0.72 | PARP1 (0.56) | PARP1DAOCHEK1 | |
| Hydrochloric Acid SCHEMBL3257058 | 0.71 | KDM4E (0.44) | CSF1RPARP1MAP2GRIN2DGRIN3B | |
| SCHEMBL20685571 | 0.71 | CHUK (0.47) | CSF1RCHEK1PIM1RPS6KA3 | |
| SCHEMBL3454039 | 0.70 | PARP1 (0.68) | PARP1DAO | |
| SCHEMBL25432291 | 0.70 | CSF1R (0.42) | CSF1RMAP2GRIN2DGRIN3BGRIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2254889-B1 | PROTEIN KINASE INHIBITORS AND USE THEREOF | MERCK PATENT GMBH (DE) | 2012-12-19 | — | — | EP | claimed |
| EP-2254889-B1 | PROTEIN KINASE INHIBITORS AND USE THEREOF | MERCK PATENT GMBH (DE) | 2012-12-19 | — | — | EP | disclosed |