Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 16/20 | 0.48 |
| ▸ | TYRO3 | Q06418 | 2/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
| ▸ | LDHA | P00338 | 1/20 | 0.44 |
| ▸ | LDHB | P07195 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14237327 | 0.91 | ATR (0.49) | ATRTYRO3MAP4K4LDHALDHB | |
| SCHEMBL14237253 | 0.90 | ATR (0.56) | ATRTYRO3 | |
| SCHEMBL14237284 | 0.84 | ATR (0.52) | ATR | |
| SCHEMBL3462155 | 0.83 | KDM4E (0.58) | ATRTYRO3MAP4K4 | |
| SCHEMBL3460865 | 0.81 | TYRO3 (0.66) | ATRTYRO3MAP4K4LDHALDHB | |
| SCHEMBL3459793 | 0.78 | ATR (0.47) | ATRTYRO3 | |
| SCHEMBL3460825 | 0.77 | ATR (0.58) | ATRMAP4K4LDHALDHB | |
| SCHEMBL14237336 | 0.77 | PIK3CD (0.49) | ATRTYRO3 | |
| SCHEMBL3460033 | 0.77 | ATR (0.53) | ATRTYRO3 | |
| SCHEMBL3461314 | 0.77 | ATR (0.46) | ATR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501514-B1 | PROTEIN KINASE MODULATORS AND METHODS OF USE | EXELIXIS INC (US) | 2012-12-19 | — | — | EP | disclosed |