Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | NPY5R | Q15761 | 6/20 | 0.43 |
| ▸ | REV1 | Q9UBZ9 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.42 |
| ▸ | MEN1 | O00255 | 5/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.42 |
| ▸ | LMNA | P02545 | 5/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | USP2 | O75604 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | RORC | P51449 | 1/20 | 0.39 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14237565 | 0.92 | MAPT (0.55) | MAPTL3MBTL1NPY5RREV1KDM4E | |
| SCHEMBL12995366 | 0.88 | MAPT (0.62) | MAPTL3MBTL1NPY5RREV1KDM4E | |
| SCHEMBL1378788 | 0.88 | MAPT (0.62) | MAPTL3MBTL1NPY5RREV1KDM4E | |
| SCHEMBL14237461 | 0.87 | MAPT (0.56) | MAPTL3MBTL1NPY5RREV1KDM4E | |
| SCHEMBL14237592 | 0.85 | MAPT (0.54) | MAPTL3MBTL1NPY5RREV1KDM4E | |
| SCHEMBL14237310 | 0.83 | ALDH1A1 (0.40) | MAPTL3MBTL1KDM4EMEN1KMT2A | |
| SCHEMBL14237770 | 0.83 | ALDH1A1 (0.40) | MAPTL3MBTL1KDM4EMEN1KMT2A | |
| SCHEMBL14237321 | 0.83 | ALDH1A1 (0.40) | MAPTL3MBTL1KDM4EMEN1KMT2A | |
| SCHEMBL14237561 | 0.81 | KMT2A (0.39) | MAPTL3MBTL1KDM4EMEN1KMT2A | |
| SCHEMBL14237392 | 0.81 | KMT2A (0.39) | MAPTL3MBTL1KDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1542993-B1 | PIPERAZINE DERIVATIVES AND METHODS OF USE | MERCK SERONO SA (CH) | 2012-12-19 | — | — | EP | claimed |