SCHEMBL14237609 — predicted protein targets

Predicted protein targets (top 9)

	gene	UniProt	supporting neighbours	confidence
▸	GPR119	Q8TDV5	5/20	0.40

▸	KDM1A	O60341	6/20	0.37

▸	CHRM2	P08172	2/20	0.36

▸	CHRM5	P08912	1/20	0.36

▸	CHRM1	P11229	1/20	0.36

▸	TRPV4	Q9HBA0	5/20	0.35

▸	JAK2	O60674	1/20	0.35

▸	TBK1	Q9UHD2	1/20	0.35

▸	BCL2A1	Q16548	1/20	0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL1550797	0.90	GPR119 (0.46)	GPR119KDM1AJAK2TBK1
SCHEMBL1550799	0.90	GPR119 (0.46)	GPR119KDM1AJAK2TBK1
SCHEMBL2458075	0.86	GPR119 (0.49)	GPR119KDM1ATRPV4
SCHEMBL2541768	0.81	GPR119 (0.51)	GPR119KDM1ATRPV4
SCHEMBL12234573	0.81	GPR119 (0.51)	GPR119KDM1ATRPV4
SCHEMBL2545449	0.81	GPR119 (0.51)	GPR119KDM1ATRPV4
SCHEMBL2541769	0.81	GPR119 (0.51)	GPR119KDM1ATRPV4
SCHEMBL1550695	0.81	GPR119 (0.51)	GPR119KDM1ATRPV4
SCHEMBL2545446	0.81	GPR119 (0.51)	GPR119KDM1ATRPV4
Hydrochloric Acid SCHEMBL1550675	0.80	GPR119 (0.40)	GPR119KDM1ATRPV4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-2313395-B1	PYRIDONE AND PYRIDAZONE ANALOGUES AS GPR119 MODULATORS	BRISTOL MYERS SQUIBB CO (US)	2012-12-19	—	—	EP	claimed