SCHEMBL1423792

SCHEMBL1423792

CCCCC(O)(Cn1ccnn1)c1ccc(Cl)cc1Cl

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP27B1 O15528 1/20 0.38
OGG1 O15527 1/20 0.36
CYP19A1 P11511 4/20 0.35
CYP3A4 P08684 5/20 0.34
CNR2 P34972 2/20 0.34
MEN1 O00255 1/20 0.34
ALDH1A1 P00352 1/20 0.34
KMT2A Q03164 1/20 0.34
CCR1 P32246 4/20 0.33
CCR2 P41597 4/20 0.33
CCR4 P51679 4/20 0.33
CYP2C9 P11712 1/20 0.33
CYP2C19 P33261 1/20 0.33
PSEN1 P49768 1/20 0.32
PSEN2 P49810 1/20 0.32
APH1B Q8WW43 1/20 0.32
NCSTN Q92542 1/20 0.32
APH1A Q96BI3 1/20 0.32
PSENEN Q9NZ42 1/20 0.32
PTGS2 P35354 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1423791 0.85 CNR2 (0.37) CYP27B1OGG1CYP3A4CNR2MEN1
SCHEMBL21772447 0.83 OGG1 (0.38) CYP27B1OGG1CYP19A1CYP3A4CNR2
SCHEMBL11129469 0.79 OGG1 (0.38) CYP27B1OGG1CYP19A1CYP3A4MEN1
Hexaconazole SCHEMBL3224781 0.79 CYP3A4 (0.50) CYP19A1CYP3A4ALDH1A1KMT2ACYP2C9
Hexaconazole SCHEMBL7171315 0.79 CYP3A4 (0.50) CYP19A1CYP3A4ALDH1A1KMT2ACYP2C9
Hexaconazole SCHEMBL29795747 0.79 CYP3A4 (0.50) CYP19A1CYP3A4ALDH1A1KMT2ACYP2C9
Hexaconazole SCHEMBL3019086 0.79 CYP3A4 (0.50) CYP19A1CYP3A4ALDH1A1KMT2ACYP2C9
Hexaconazole SCHEMBL21992 0.79 CYP3A4 (0.50) CYP19A1CYP3A4ALDH1A1KMT2ACYP2C9
Hexaconazole SCHEMBL29368626 0.79 CYP3A4 (0.50) CYP19A1CYP3A4ALDH1A1KMT2ACYP2C9
SCHEMBL11191705 0.79 OGG1 (0.55) CYP27B1OGG1CYP19A1CYP3A4ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2160427-B1 GRANULE COATED WITH URETHANE RESIN SUMITOMO CHEMICAL CO (JP) 2011-03-23 EP disclosed
EP-0110536-B1 SUBSTITUTED ALKENES AND PROCESSES FOR THEIR PREPARATION IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1988-09-21 EP disclosed
EP-0235714-A1 Process for the preparation of compounds with a double carbon to carbon bond by dehydration of the corresponding alcohol IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1987-09-09 EP disclosed
EP-0110536-A2 Substituted alkenes and processes for their preparation IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1984-06-13 EP disclosed