Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 6/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 5/20 | 0.36 |
| ▸ | LMNA | P02545 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.34 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.33 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | APP | P05067 | 1/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.33 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.33 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14239103 | 0.83 | RAB9A (0.45) | RAB9AMAPTHTTNPC1LMNA | |
| SCHEMBL14239815 | 0.83 | RAB9A (0.38) | RAB9AMAPTHTTNPC1LMNA | |
| SCHEMBL14239835 | 0.82 | RAB9A (0.43) | RAB9AMAPTHTTNPC1LMNA | |
| SCHEMBL14239822 | 0.82 | HTT (0.36) | RAB9AMAPTHTTNPC1LMNA | |
| SCHEMBL14239330 | 0.82 | MAPT (0.38) | RAB9AMAPTHTTNPC1LMNA | |
| SCHEMBL14239122 | 0.81 | RAB9A (0.38) | RAB9AMAPTHTTNPC1LMNA | |
| SCHEMBL14238876 | 0.81 | RAB9A (0.38) | RAB9AMAPTHTTNPC1LMNA | |
| SCHEMBL14239953 | 0.81 | NPC1 (0.44) | RAB9AMAPTNPC1LMNAALDH1A1 | |
| SCHEMBL14239812 | 0.81 | RAB9A (0.38) | RAB9AMAPTHTTNPC1LMNA | |
| SCHEMBL14239130 | 0.81 | MAPT (0.42) | RAB9AMAPTHTTNPC1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012170845-A2 | METABOTROPIC GLUTAMATE RECEPTOR 5 MODULATORS AND METHODS OF USE THEREOF | HEFFERNAN MICHELE L R (US) | 2012-12-13 | — | — | WO | disclosed |