Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 18/20 | 0.59 |
| ▸ | MTOR | P42345 | 17/20 | 0.59 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.46 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.46 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.46 |
| ▸ | PIK3C2A | O00443 | 2/20 | 0.46 |
| ▸ | PIK3C2B | O00750 | 2/20 | 0.46 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.46 |
| ▸ | PRKDC | P78527 | 2/20 | 0.46 |
| ▸ | ATM | Q13315 | 2/20 | 0.46 |
| ▸ | ATR | Q13535 | 2/20 | 0.46 |
| ▸ | RPTOR | Q8N122 | 2/20 | 0.46 |
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.46 |
| ▸ | MLST8 | Q9BVC4 | 2/20 | 0.46 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.46 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.46 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.44 |
| ▸ | JAK3 | P52333 | 2/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.44 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20430353 | 0.90 | MTOR (0.73) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL15641504 | 0.90 | PIK3CA (0.49) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL14240428 | 0.89 | PIK3CA (0.59) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL20430570 | 0.89 | PIK3CA (0.61) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL14239224 | 0.88 | MTOR (0.74) | PIK3CAMTOR | |
| SCHEMBL14240422 | 0.88 | PIK3CA (0.58) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL18174471 | 0.88 | PIK3CA (0.58) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL18174464 | 0.87 | MTOR (0.57) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL15641463 | 0.87 | MTOR (0.57) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL14239575 | 0.86 | PIK3CA (0.74) | PIK3CAMTORPIK3CDPIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9475812-B2 | Pyridonaphthyridine type dual PI3K and mTOR inhibitor and its preparation and use | Xuanzhu Pharma Co., Ltd. (CN) | 2016-10-25 | — | — | US | claimed |
| EP-2719697-B1 | PYRIDONAPHTHYRIDINE PI3K/MTOR DUAL INHIBITORS AND PREPARATION AND USE THEREOF | XUANZHU PHARMA CO LTD (CN) | 2018-08-01 | — | — | EP | disclosed |
| EP-2719697-B1 | PYRIDONAPHTHYRIDINE PI3K/MTOR DUAL INHIBITORS AND PREPARATION AND USE THEREOF | XUANZHU PHARMA CO LTD (CN) | 2018-08-01 | — | — | EP | disclosed |
| US-9475812-B2 | Pyridonaphthyridine type dual PI3K and mTOR inhibitor and its preparation and use | Xuanzhu Pharma Co., Ltd. (CN) | 2016-10-25 | — | — | US | disclosed |
| US-9475812-B2 | Pyridonaphthyridine type dual PI3K and mTOR inhibitor and its preparation and use | Xuanzhu Pharma Co., Ltd. (CN) | 2016-10-25 | — | — | US | disclosed |
| US-9475812-B2 | Pyridonaphthyridine type dual PI3K and mTOR inhibitor and its preparation and use | Xuanzhu Pharma Co., Ltd. (CN) | 2016-10-25 | — | — | US | disclosed |
| EP-2719697-A1 | PYRIDONAPHTHYRIDINE PI3K/MTOR DUAL INHIBITORS AND PREPARATION AND USE THEREOF | Xuanzhu Pharma Co., Ltd. (CN) | 2014-04-16 | — | — | EP | disclosed |
| WO-2012167606-A1 | PYRIDONAPHTHYRIDINE PI3K/MTOR DUAL INHIBITORS AND PREPARATION AND USE THEREOF | 山东亨利医药科技有限责任公司 (CN) | 2012-12-13 | — | — | WO | disclosed |