Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 18/20 | 0.58 |
| ▸ | MTOR | P42345 | 17/20 | 0.58 |
| ▸ | PIK3CD | O00329 | 5/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.42 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.42 |
| ▸ | PRKDC | P78527 | 2/20 | 0.42 |
| ▸ | ATM | Q13315 | 2/20 | 0.42 |
| ▸ | ATR | Q13535 | 2/20 | 0.42 |
| ▸ | PIK3C2A | O00443 | 1/20 | 0.42 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.42 |
| ▸ | CSF1R | P07333 | 1/20 | 0.42 |
| ▸ | MET | P08581 | 1/20 | 0.42 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.42 |
| ▸ | LTK | P29376 | 1/20 | 0.42 |
| ▸ | CDK7 | P50613 | 1/20 | 0.42 |
| ▸ | NEK2 | P51955 | 1/20 | 0.42 |
| ▸ | JAK3 | P52333 | 1/20 | 0.42 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18174464 | 0.92 | MTOR (0.57) | PIK3CAMTORPIK3CDPIK3CGPIK3CB | |
| SCHEMBL20430353 | 0.88 | MTOR (0.73) | PIK3CAMTORPIK3CDPIK3CGPIK3CB | |
| SCHEMBL14240428 | 0.88 | PIK3CA (0.59) | PIK3CAMTORPIK3CDPIK3CGPIK3CB | |
| SCHEMBL14239222 | 0.88 | PIK3CA (0.59) | PIK3CAMTORPIK3CDPIK3CGPIK3CB | |
| SCHEMBL20430570 | 0.87 | PIK3CA (0.61) | PIK3CAMTORPIK3CDPIK3CGPIK3CB | |
| SCHEMBL14240422 | 0.86 | PIK3CA (0.58) | PIK3CAMTORPIK3CDPIK3CGPIK3CB | |
| SCHEMBL14239224 | 0.86 | MTOR (0.74) | PIK3CAMTOR | |
| SCHEMBL18174467 | 0.86 | PIK3CA (0.56) | PIK3CAMTORPIK3CDPIK3CGPIK3CB | |
| SCHEMBL15641463 | 0.85 | MTOR (0.57) | PIK3CAMTORPIK3CDPIK3CGPIK3CB | |
| SCHEMBL14239575 | 0.85 | PIK3CA (0.74) | PIK3CAMTORPIK3CDPIK3CGPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9475812-B2 | Pyridonaphthyridine type dual PI3K and mTOR inhibitor and its preparation and use | Xuanzhu Pharma Co., Ltd. (CN) | 2016-10-25 | — | — | US | disclosed |