Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 15/20 | 0.51 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.39 |
| ▸ | IKBKB | O14920 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | GPR6 | P46095 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14157572 | 0.96 | GPR119 (0.55) | GPR119MDM2IKBKBCYP2C9CYP2C19 | |
| SCHEMBL14157573 | 0.96 | GPR119 (0.55) | GPR119MDM2IKBKBCYP2C9CYP2C19 | |
| SCHEMBL14157661 | 0.88 | GPR119 (0.43) | GPR119MDM2GPR6 | |
| SCHEMBL14239772 | 0.88 | GPR119 (0.43) | GPR119MDM2GPR6 | |
| SCHEMBL14239773 | 0.83 | GPR119 (0.50) | GPR119MDM2GPR6 | |
| SCHEMBL15691866 | 0.82 | GPR119 (0.43) | GPR119IKBKBGPR6 | |
| SCHEMBL14157722 | 0.81 | GPR119 (0.54) | GPR119GPR6 | |
| SCHEMBL14157723 | 0.81 | GPR119 (0.54) | GPR119GPR6 | |
| SCHEMBL14157655 | 0.80 | GPR119 (0.52) | GPR119GPR6 | |
| SCHEMBL14157656 | 0.80 | GPR119 (0.52) | GPR119GPR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012170702-A1 | MODULATORS OF THE GPR119 RECEPTOR AND THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2012-12-13 | — | — | WO | disclosed |