Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 2/20 | 0.34 |
| ▸ | FEN1 | P39748 | 2/20 | 0.34 |
| ▸ | AKT1 | P31749 | 7/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.33 |
| ▸ | CDK2 | P24941 | 4/20 | 0.33 |
| ▸ | STIM1 | Q13586 | 3/20 | 0.33 |
| ▸ | ORAI1 | Q96D31 | 3/20 | 0.33 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15003811 | 0.83 | STIM1 (0.41) | AKT1MAPK14STIM1ORAI1LIMK1 | |
| SCHEMBL14239588 | 0.71 | MEN1 (0.40) | MAPK14LIMK1 | |
| SCHEMBL14999204 | 0.71 | KDM4E (0.49) | MAPK14STIM1ORAI1LIMK1 | |
| SCHEMBL14239590 | 0.70 | STIM1 (0.40) | ALOX5APFEN1MAPK14STIM1ORAI1 | |
| SCHEMBL14999202 | 0.70 | TP53 (0.44) | MAPK14STIM1ORAI1LIMK1 | |
| SCHEMBL14239143 | 0.70 | ESR2 (0.46) | MAPK14STIM1ORAI1LIMK1 | |
| SCHEMBL14158695 | 0.67 | STIM1 (0.63) | STIM1ORAI1HDAC6 | |
| SCHEMBL14240001 | 0.67 | STIM1 (0.66) | MAPK14STIM1ORAI1LIMK1 | |
| SCHEMBL14999200 | 0.63 | STIM1 (0.47) | MAPK14STIM1ORAI1 | |
| SCHEMBL14239142 | 0.62 | STIM1 (0.39) | AKT1CDK2STIM1ORAI1LIMK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012170951-A2 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | CALCIMEDICA, INC. (US) | 2012-12-13 | — | — | WO | disclosed |