Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STIM1 | Q13586 | 3/20 | 0.39 |
| ▸ | ORAI1 | Q96D31 | 3/20 | 0.39 |
| ▸ | AKT1 | P31749 | 3/20 | 0.32 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.31 |
| ▸ | CDK2 | P24941 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14158528 | 0.75 | STIM1 (0.52) | STIM1ORAI1 | |
| SCHEMBL14158695 | 0.67 | STIM1 (0.63) | STIM1ORAI1 | |
| SCHEMBL31081360 | 0.64 | PIM1 (0.38) | — | |
| SCHEMBL14239239 | 0.64 | STIM1 (0.55) | STIM1ORAI1LIMK1 | |
| SCHEMBL15375205 | 0.63 | CA2 (0.33) | — | |
| SCHEMBL14240075 | 0.62 | STIM1 (0.50) | STIM1ORAI1LIMK1 | |
| SCHEMBL14240442 | 0.62 | ALOX5AP (0.34) | STIM1ORAI1AKT1LIMK1CDK2 | |
| SCHEMBL14239031 | 0.61 | STIM1 (0.65) | STIM1ORAI1 | |
| SCHEMBL3471586 | 0.60 | FLT3 (0.40) | — | |
| SCHEMBL14999200 | 0.60 | STIM1 (0.47) | STIM1ORAI1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012170951-A2 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | CALCIMEDICA, INC. (US) | 2012-12-13 | — | — | WO | disclosed |