Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.57 |
| ▸ | MEN1 | O00255 | 4/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.57 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.57 |
| ▸ | P2RY1 | P47900 | 13/20 | 0.56 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.53 |
| ▸ | CCR2 | P41597 | 1/20 | 0.52 |
| ▸ | P2RY14 | Q15391 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1424512 | 0.87 | P2RY1 (0.63) | P2RY1CCR2P2RY14SLC22A12 | |
| SCHEMBL1425241 | 0.86 | P2RY1 (0.65) | KMT2AGLO1P2RY1POLBCCR2 | |
| SCHEMBL1424890 | 0.84 | P2RY1 (0.58) | P2RY1CCR2P2RY14 | |
| SCHEMBL1424702 | 0.84 | P2RY1 (0.53) | P2RY1CCR2P2RY14SLC22A12 | |
| SCHEMBL1425270 | 0.84 | P2RY1 (0.54) | KMT2AP2RY1POLBCCR2P2RY14 | |
| SCHEMBL3446082 | 0.84 | P2RY1 (0.66) | KMT2AGLO1P2RY1POLBP2RY14 | |
| SCHEMBL3446360 | 0.83 | P2RY1 (0.68) | KMT2AP2RY1POLBP2RY14ALDH1A1 | |
| SCHEMBL3446428 | 0.83 | SLC40A1 (0.51) | GLO1P2RY1POLBCCR2P2RY14 | |
| SCHEMBL3446186 | 0.82 | P2RY1 (0.61) | P2RY1CCR2P2RY14SLC22A12 | |
| SCHEMBL1424674 | 0.82 | SLC22A12 (0.54) | P2RY1POLBP2RY14ALDH1A1SLC22A12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7816382-B2 | Linear urea mimics antagonists of P2Y1 receptor useful in the treatment of thrombotic condition | BRISTOL-MYERS SQUIBB COMPANY (US) | 2010-10-19 | — | — | US | claimed |
| EP-1896417-B1 | LINEAR UREA MIMICS ANTAGONISTS OF P2Y1 RECEPTOR USEFUL IN THE TREATMENT OF THROMBOTIC CONDITIONS | BRISTOL MYERS SQUIBB CO (US) | 2011-03-23 | — | — | EP | disclosed |