SLC40A1 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL414126	1.00	19/20
SCHEMBL414125	1.00	18/20
SCHEMBL460773	1.00	17/20
Hydrochloric Acid (SCHEMBL1098254)	0.51	16/20
SCHEMBL1379086	0.78	15/20
SCHEMBL416275	0.70	15/20
SCHEMBL1319547	0.82	14/20
SCHEMBL1034381	0.59	14/20
SCHEMBL1097665	0.52	14/20
SCHEMBL1110190	0.77	13/20
SCHEMBL463479	0.55	12/20
SCHEMBL442367	1.00	11/20
SCHEMBL1099148	0.52	11/20
SCHEMBL1107216	0.46	11/20
Hydrochloric Acid (SCHEMBL1101425)	0.45	11/20
SCHEMBL416258	0.58	10/20
SCHEMBL1377405	0.54	10/20
SCHEMBL1207409	0.62	8/20
SCHEMBL1110218	0.50	7/20
SCHEMBL789565	0.57	6/20

Clinical trials — most relevant to SLC40A1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Bovine Lactoferrin to Prevent and Cure Iron Deficiency and Iron Deficiency Anemia in Complicated Pregnancies	PHASE4	COMPLETED
Intravenous Iron for Treatment of Anaemia Before Cardiac Surgery	PHASE4	COMPLETED
Anemia Therapy in Patients With Infective Endocarditis	PHASE4	RECRUITING
Analysis of the Modulation of Serum Hepcidin Level in Response to Iron Oral Intake: Potential Interest for the Differential Diagnosis Between Ferroportin Disease and Dysmetabolic Hepatosiderosis.	PHASE2	COMPLETED
Treatment of Iron Overload With Deferasirox (Exjade) in Hereditary Hemochromatosis and Myelodysplastic Syndrome	PHASE2	WITHDRAWN
Enhancing Treatment of Iron Deficiency and Iron Deficiency Anemia With an Antioxidant, Vitamin E	PHASE1	COMPLETED
Effects of Vitamin D Replacement on Hormones Regulating Iron Metabolism in Individuals With Chronic Kidney Disease	EARLY_PHASE1	COMPLETED
Role of USP35 in the Detection of Ferroptosis in Juvenile Autoimmune Hepatitis	nan	NOT_YET_RECRUITING
Incidence of Iron Deficiency in Polycythemia Vera (PV) and Association With Disease Features	nan	UNKNOWN
Iron Deficiency in Heart Failure Patients	nan	UNKNOWN
Out Come Study To Define Laboratory Parameters That Are Best Suited to Diagnose Functional Iron Deficiency	nan	COMPLETED
Genetic Variants and Iron Absorption	nan	COMPLETED
Prohepcidin, Inflammation and Iron Homeostasis in Hemodialysis Patients With Chronic Hepatitis C	nan	COMPLETED
Study of Serum Hepcidin Rate Variations During Menstrual Cycle	nan	COMPLETED
Effect of Taking a Single Tablet of Iron on Insulin Secretion	nan	COMPLETED
The Correlation Between Anemia of Chronic Diseases, Hepcidin and Vitamin D in IBD Patients	nan	UNKNOWN
Genes-in-Action - Hepcidin Regulation of Iron Supplementation	nan	COMPLETED
Mitoferrin-1 Expression in Erythropoietic Protoporphyria (Porphyria Rare Disease Clinical Research Consortium (RDCRC))	nan	COMPLETED
The Immunomodulatory Effects of Phlebotomy	nan	UNKNOWN
Changes in Iron Absorption and Availability Before and After Weight Loss in Obese Pre-menopausal Women and Men.	nan	COMPLETED
Zinc and Diabetes in Patients With Thalassemia: a Pilot Study	nan	COMPLETED
GDF 15 in Sickle Cell Disease and Hereditary Spherocytosis	nan	UNKNOWN
Omega-3 Fatty Acid Supplementation and Fractional Iron Absorption in Obese South African Women	nan	COMPLETED
Iron Isotope Study of an Iron Fatty Acid Complex	nan	COMPLETED
Effect of Age and Weight Loss on Inflammation and Iron Homeostasis	nan	COMPLETED
Hepcidin and Anemia in Trauma	nan	COMPLETED
Impact of Vitamin D Supplementation on Hepcidin Levels and Transfusion Requirements in Surgical and Septic Patients	nan	UNKNOWN
Hemochromatosis and Iron Overload Screening Study (HEIRS)	nan	COMPLETED
Absorption of Heme and Non-Heme Iron in Pregnant and Non-pregnant Women and Mechanisms of Fetal Iron Transfer	nan	COMPLETED
Mechanism of Decreased Iron Absorption in Obesity: Controlling Adiposity-related Inflammation	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a SLC40A1 binder may also engage these)

Protein	Name	Similarity
Q9JHI9	—	1.000	Q9JHI9 →
Q923U9	—	1.000	Q923U9 →
E2RFJ3	—	1.000	E2RFJ3 →
Q9I9R3	—	0.997	Q9I9R3 →
Q6YK44	—	0.979	Q6YK44 →
Q8NHS3	—	0.978	Q8NHS3 →
Q8NA29	—	0.977	Q8NA29 →
B8AF63	—	0.975	B8AF63 →
Q0VA82	—	0.972	Q0VA82 →
A1L272	—	0.970	A1L272 →
Q8BH31	—	0.970	Q8BH31 →
Q6DEJ6	—	0.969	Q6DEJ6 →
O80605	—	0.968	O80605 →
Q8R070	—	0.966	Q8R070 →
Q640L2	—	0.966	Q640L2 →
Q5U3U7	—	0.964	Q5U3U7 →
Q0IHM1	—	0.963	Q0IHM1 →
Q9DA75	—	0.961	Q9DA75 →
Q6GQE1	—	0.961	Q6GQE1 →
Q8R139	—	0.960	Q8R139 →
SLC11A2	Natural resistance-associated macrophage protein 2	0.959	landscape →
Q6GPQ3	—	0.958	Q6GPQ3 →
Q8WV83	—	0.957	Q8WV83 →
P57057	—	0.956	P57057 →
Q5F3N0	—	0.956	Q5F3N0 →
Q8NCC5	—	0.955	Q8NCC5 →
Q3TIT8	—	0.955	Q3TIT8 →
A4IH46	—	0.955	A4IH46 →
Q5TF39	—	0.955	Q5TF39 →
SLC43A3	Equilibrative nucleobase transporter 1	0.954	landscape →