Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 10/20 | 0.64 |
| ▸ | S1PR4 | O95977 | 9/20 | 0.64 |
| ▸ | S1PR3 | Q99500 | 9/20 | 0.64 |
| ▸ | S1PR5 | Q9H228 | 8/20 | 0.64 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | CASP1 | P29466 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.49 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.49 |
| ▸ | NR5A1 | Q13285 | 1/20 | 0.49 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.48 |
| ▸ | TNNC1 | P63316 | 5/20 | 0.47 |
| ▸ | SGPL1 | O95470 | 1/20 | 0.47 |
| ▸ | GPR183 | P32249 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6021227 | 1.00 | S1PR1 (0.64) | S1PR1S1PR4S1PR3S1PR5MEN1 | |
| SCHEMBL14246873 | 1.00 | S1PR1 (0.64) | S1PR1S1PR4S1PR3S1PR5MEN1 | |
| SCHEMBL1626412 | 0.91 | S1PR1 (0.62) | S1PR1S1PR4S1PR3S1PR5MEN1 | |
| SCHEMBL1626931 | 0.91 | S1PR1 (0.62) | S1PR1S1PR4S1PR3S1PR5MEN1 | |
| SCHEMBL1624918 | 0.91 | S1PR1 (0.62) | S1PR1S1PR4S1PR3S1PR5MEN1 | |
| SCHEMBL13844525 | 0.91 | S1PR1 (0.62) | S1PR1S1PR4S1PR3S1PR5MEN1 | |
| SCHEMBL1626974 | 0.91 | S1PR1 (0.62) | S1PR1S1PR4S1PR3S1PR5MEN1 | |
| SCHEMBL1626883 | 0.90 | S1PR1 (0.61) | S1PR1S1PR4S1PR3S1PR5MEN1 | |
| SCHEMBL1626653 | 0.90 | S1PR1 (0.61) | S1PR1S1PR4S1PR3S1PR5MEN1 | |
| SCHEMBL14246856 | 0.87 | FFAR1 (0.52) | S1PR1S1PR4S1PR3S1PR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9763980-B2 | Combined chemical modification of sphingosine-1-phosphate (S1P) and CXCR4 signalling pathways for hematopoietic stem cell (HSC) mobilization and engraftment | CHILDREN'S MEDICAL CENTER CORPORATION (US) | 2017-09-19 | — | — | US | disclosed |
| US-20140193376-A1 | COMBINED CHEMICAL MODIFICATION OF SPHINGOSINE-1-PHOSPHATE (S1P) AND CXCR4 SIGNALLING PATHWAYS FOR HEMATOPOIETIC STEM CELL (HSC) MOBILIZATION AND ENGRAFTMENT | CHILDREN'S MEDICAL CENTER CORPORATION (US) | 2014-07-10 | — | — | US | disclosed |
| EP-2720690-A1 | COMBINED CHEMICAL MODIFICATION OF SPHINGOSINE-1-PHOSPHATE (S1P) AND CXCR4 SIGNALLING PATHWAYS FOR HEMATOPOIETIC STEM CELL (HSC) MOBILIZATION AND ENGRAFTMENT | Children's Medical Center Corporation (US) | 2014-04-23 | — | — | EP | disclosed |
| WO-2012174522-A1 | COMBINED CHEMICAL MODIFICATION OF SPHINGOSINE-1-PHOSPHATE (S1P) AND CXCR4 SIGNALLING PATHWAYS FOR HEMATOPOIETIC STEM CELL (HSC) MOBILIZATION AND ENGRAFTMENT | CHILDREN'S MEDICAL CENTER CORPORATION (US) | 2012-12-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140193376-A1 | COMBINED CHEMICAL MODIFICATION OF SPHINGOSINE-1-PHOSPHATE (S1P) AND CXCR4 SIGNALLING PATHWAYS FOR HEMATOPOIETIC STEM CELL (HSC) MOBILIZATION AND ENGRAFTMENT | S1PR1, S1PR4, S1PR3 | S1PR1 1/4885S1PR4 2/4885S1PR3 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.