Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 10/20 | 0.62 |
| ▸ | S1PR4 | O95977 | 9/20 | 0.62 |
| ▸ | S1PR3 | Q99500 | 9/20 | 0.62 |
| ▸ | S1PR5 | Q9H228 | 8/20 | 0.62 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | CASP1 | P29466 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.48 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.48 |
| ▸ | NR5A1 | Q13285 | 1/20 | 0.48 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.47 |
| ▸ | TNNC1 | P63316 | 4/20 | 0.46 |
| ▸ | SGPL1 | O95470 | 1/20 | 0.46 |
| ▸ | GPR183 | P32249 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1624918 | 1.00 | S1PR1 (0.62) | S1PR1S1PR4S1PR3S1PR5MEN1 | |
| SCHEMBL1626974 | 1.00 | S1PR1 (0.62) | S1PR1S1PR4S1PR3S1PR5MEN1 | |
| SCHEMBL13844525 | 1.00 | S1PR1 (0.62) | S1PR1S1PR4S1PR3S1PR5MEN1 | |
| SCHEMBL1626931 | 1.00 | S1PR1 (0.62) | S1PR1S1PR4S1PR3S1PR5MEN1 | |
| SCHEMBL6021227 | 0.91 | S1PR1 (0.64) | S1PR1S1PR4S1PR3S1PR5MEN1 | |
| SCHEMBL14246873 | 0.91 | S1PR1 (0.64) | S1PR1S1PR4S1PR3S1PR5MEN1 | |
| SCHEMBL14246795 | 0.91 | S1PR1 (0.64) | S1PR1S1PR4S1PR3S1PR5MEN1 | |
| SCHEMBL1626653 | 0.88 | S1PR1 (0.61) | S1PR1S1PR4S1PR3S1PR5MEN1 | |
| SCHEMBL1626883 | 0.88 | S1PR1 (0.61) | S1PR1S1PR4S1PR3S1PR5MEN1 | |
| SCHEMBL1625887 | 0.88 | S1PR1 (0.49) | S1PR1S1PR4S1PR3S1PR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1753712-B1 | AMINO-PROPANOL DERIVATIVES | NOVARTIS AG (CH) | 2009-05-13 | — | — | EP | claimed |
| US-20070225260-A1 | Amino-Propanol Derivatives | NOVARTIS AG (CH) | 2007-09-27 | — | — | US | claimed |
| EP-1753712-A1 | AMINO-PROPANOL DERIVATIVES | Novartis AG (CH) | 2007-02-21 | — | — | EP | claimed |
| WO-2005118523-A1 | AMINO-PROPANOL DERIVATIVES | NOVARTIS AG (CH) | 2005-12-15 | — | — | WO | claimed |
| US-7928093-B2 | Amino-propanol derivatives | NOVARTIS AG (CH) | 2011-04-19 | — | — | US | disclosed |
| US-7928093-B2 | Amino-propanol derivatives | NOVARTIS AG (CH) | 2011-04-19 | — | — | US | disclosed |
| US-7928093-B2 | Amino-propanol derivatives | NOVARTIS AG (CH) | 2011-04-19 | — | — | US | disclosed |
| EP-1753712-B1 | AMINO-PROPANOL DERIVATIVES | NOVARTIS AG (CH) | 2009-05-13 | — | — | EP | disclosed |
| EP-1753712-B1 | AMINO-PROPANOL DERIVATIVES | NOVARTIS AG (CH) | 2009-05-13 | — | — | EP | disclosed |
| WO-2009056993-A2 | A PROCESS FOR THE SYNTHESIS OF RAMELTEON AND ITS INTERMEDIATES | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2009-05-07 | — | — | WO | disclosed |
| US-20070225260-A1 | Amino-Propanol Derivatives | NOVARTIS AG (CH) | 2007-09-27 | — | — | US | disclosed |
| US-20070225260-A1 | Amino-Propanol Derivatives | NOVARTIS AG (CH) | 2007-09-27 | — | — | US | disclosed |
| US-20070225260-A1 | Amino-Propanol Derivatives | NOVARTIS AG (CH) | 2007-09-27 | — | — | US | disclosed |
| EP-1753712-A1 | AMINO-PROPANOL DERIVATIVES | Novartis AG (CH) | 2007-02-21 | — | — | EP | disclosed |
| WO-2005118523-A1 | AMINO-PROPANOL DERIVATIVES | NOVARTIS AG (CH) | 2005-12-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070225260-A1 | Amino-Propanol Derivatives | ADRB1, ADRB3, ARG1 | S1PR1 1545/4885S1PR4 2354/4885S1PR3 877/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.