Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 1/20 | 0.50 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.49 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.49 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.49 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.49 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.46 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.46 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.46 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.46 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.46 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | PREP | P48147 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21241492 | 0.85 | HTR2C (0.52) | HTR2CPDK1PDK2PDK3PDK4 | |
| SCHEMBL12293392 | 0.81 | SMN1; SMN2 (0.47) | HTR2CPDK1PDK2PDK3PDK4 | |
| SCHEMBL2438212 | 0.81 | HTR2C (0.48) | HTR2CPDK1PDK2PDK3PDK4 | |
| SCHEMBL7714230 | 0.81 | HTR2C (0.48) | HTR2CPDK1PDK2PDK3PDK4 | |
| SCHEMBL20656916 | 0.80 | PDK1 (0.49) | HTR2CPDK1PDK2PDK3PDK4 | |
| SCHEMBL2435263 | 0.80 | PDK1 (0.49) | HTR2CPDK1PDK2PDK3PDK4 | |
| SCHEMBL2592306 | 0.79 | MEN1 (0.59) | HTR2CSMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL12327550 | 0.79 | PDK1 (0.44) | HTR2CPDK1PDK2PDK3PDK4 | |
| SCHEMBL12293389 | 0.79 | PDK1 (0.44) | HTR2CPDK1PDK2PDK3PDK4 | |
| SCHEMBL28411733 | 0.79 | HTR2C (0.59) | HTR2CPDK1PDK2PDK3PDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012172449-A1 | LACTAMS AS BETA SECRETASE INHIBITORS | PFIZER INC. (US) | 2012-12-20 | — | — | WO | disclosed |