Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KA5 | O75582 | 6/20 | 0.60 |
| ▸ | RPS6KB1 | P23443 | 10/20 | 0.58 |
| ▸ | ROCK1 | Q13464 | 10/20 | 0.58 |
| ▸ | PRKACA | P17612 | 8/20 | 0.55 |
| ▸ | GSK3B | P49841 | 7/20 | 0.55 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4715626 | 0.86 | RPS6KA5 (0.65) | RPS6KA5RPS6KB1ROCK1PRKACAGSK3B | |
| SCHEMBL4714655 | 0.82 | ROCK1 (0.66) | RPS6KA5RPS6KB1ROCK1PRKACAGSK3B | |
| SCHEMBL4715356 | 0.80 | ROCK1 (0.69) | RPS6KA5RPS6KB1ROCK1PRKACAGSK3B | |
| SCHEMBL4714882 | 0.79 | RPS6KB1 (0.53) | RPS6KA5RPS6KB1ROCK1PRKACAGSK3B | |
| SCHEMBL4714229 | 0.76 | ROCK1 (0.68) | RPS6KA5RPS6KB1ROCK1PRKACAGSK3B | |
| SCHEMBL4718814 | 0.75 | RPS6KA5 (1.00) | RPS6KA5RPS6KB1ROCK1PRKACAGSK3B | |
| SCHEMBL4716813 | 0.74 | RPS6KB1 (0.59) | RPS6KA5RPS6KB1ROCK1PRKACAGSK3B | |
| SCHEMBL6401655 | 0.73 | RPS6KB1 (1.00) | RPS6KA5RPS6KB1ROCK1PRKACAGSK3B | |
| SCHEMBL4003939 | 0.72 | ROCK1 (0.60) | RPS6KA5RPS6KB1ROCK1PRKACAGSK3B | |
| SCHEMBL4717559 | 0.71 | RPS6KA5 (0.93) | RPS6KA5RPS6KB1ROCK1PRKACAGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7348339-B2 | 2-(4-amino-furazan-3-yl)-1-ethyl-N-[(2R)-2-morpholinylmethyl]-1H-imidazo[4,5-c]pyridine-7-carboxamide; Mitogen- and Stress-Activated Protein (MSK) and Rho (guanosine triphosphate) 1 or 2 kinase inhibitor; neurodegenerative diaeases; antiinflammatory, anticarcinogenic, antiviral and antibacterial agent | GLAXO GROUP LIMITED (GB) | 2008-03-25 | — | — | US | disclosed |
| US-7348339-B2 | 2-(4-amino-furazan-3-yl)-1-ethyl-N-[(2R)-2-morpholinylmethyl]-1H-imidazo[4,5-c]pyridine-7-carboxamide; Mitogen- and Stress-Activated Protein (MSK) and Rho (guanosine triphosphate) 1 or 2 kinase inhibitor; neurodegenerative diaeases; antiinflammatory, anticarcinogenic, antiviral and antibacterial agent | GLAXO GROUP LIMITED (GB) | 2008-03-25 | — | — | US | disclosed |