Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHUK | O15111 | 15/20 | 0.74 |
| ▸ | ICOSLG | O75144 | 12/20 | 0.74 |
| ▸ | ICOS | Q9Y6W8 | 12/20 | 0.74 |
| ▸ | IKBKB | O14920 | 2/20 | 0.71 |
| ▸ | MEN1 | O00255 | 1/20 | 0.71 |
| ▸ | PIM1 | P11309 | 1/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.71 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.71 |
| ▸ | IKBKG | Q9Y6K9 | 1/20 | 0.71 |
| ▸ | TYK2 | P29597 | 1/20 | 0.53 |
| ▸ | CLK1 | P49759 | 1/20 | 0.53 |
| ▸ | CLK2 | P49760 | 1/20 | 0.53 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.53 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.53 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14253063 | 0.85 | CHUK (1.00) | CHUKICOSLGICOSIKBKBMEN1 | |
| SCHEMBL13376947 | 0.84 | ICOSLG (0.74) | CHUKICOSLGICOSIKBKBMEN1 | |
| SCHEMBL1420453 | 0.83 | CHUK (1.00) | CHUKICOSLGICOSIKBKBMEN1 | |
| SCHEMBL29359984 | 0.83 | CHUK (1.00) | CHUKICOSLGICOSIKBKBMEN1 | |
| Hydrochloric Acid SCHEMBL12471533 | 0.82 | CHUK (0.98) | CHUKICOSLGICOSIKBKBMEN1 | |
| SCHEMBL13377079 | 0.82 | CHUK (0.82) | CHUKICOSLGICOSIKBKBMEN1 | |
| SCHEMBL14253037 | 0.82 | CHUK (1.00) | CHUKICOSLGICOSIKBKBMEN1 | |
| SCHEMBL13377038 | 0.82 | CHUK (1.00) | CHUKICOSLGICOSIKBKBMEN1 | |
| SCHEMBL13376959 | 0.81 | CHUK (0.89) | CHUKICOSLGICOSIKBKBMEN1 | |
| SCHEMBL2768947 | 0.79 | CHUK (0.78) | CHUKICOSLGICOSIKBKBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7348336-B2 | Substituted β-carbolines | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2008-03-25 | — | — | US | disclosed |
| US-7348336-B2 | Substituted β-carbolines | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2008-03-25 | — | — | US | disclosed |