Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAMK2D | Q13557 | 6/20 | 0.63 |
| ▸ | PLK1 | P53350 | 1/20 | 0.58 |
| ▸ | PIK3CG | P48736 | 6/20 | 0.56 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.56 |
| ▸ | PIK3CB | P42338 | 5/20 | 0.56 |
| ▸ | ABL1 | P00519 | 2/20 | 0.55 |
| ▸ | BCR | P11274 | 2/20 | 0.55 |
| ▸ | PRKCA | P17252 | 1/20 | 0.55 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.55 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.55 |
| ▸ | JAK2 | O60674 | 2/20 | 0.53 |
| ▸ | EGFR | P00533 | 1/20 | 0.53 |
| ▸ | CDK2 | P24941 | 1/20 | 0.53 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.53 |
| ▸ | FLT3 | P36888 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12800918 | 0.95 | CAMK2D (0.67) | CAMK2DPLK1PIK3CGPIK3CAPIK3CB | |
| SCHEMBL14253954 | 0.91 | PIK3CG (0.59) | CAMK2DPIK3CGPIK3CAPIK3CBABL1 | |
| SCHEMBL14254251 | 0.89 | PIK3CG (0.65) | CAMK2DPIK3CGPIK3CAPIK3CBCDK5 | |
| SCHEMBL14254249 | 0.88 | PIK3CG (0.59) | CAMK2DPIK3CGPIK3CAPIK3CBABL1 | |
| SCHEMBL14254242 | 0.88 | JAK2 (0.56) | CAMK2DPLK1PIK3CGPIK3CAPIK3CB | |
| SCHEMBL12801118 | 0.86 | CDK5 (0.73) | CAMK2DPLK1PIK3CGPIK3CAPIK3CB | |
| SCHEMBL14253949 | 0.85 | PIK3CG (0.73) | PIK3CGPIK3CAPIK3CBABL1BCR | |
| SCHEMBL12275494 | 0.85 | PLK1 (0.70) | CAMK2DPLK1PIK3CGPIK3CAPIK3CB | |
| SCHEMBL14253944 | 0.85 | IKBKB (0.61) | CAMK2DPIK3CGPIK3CAPIK3CBABL1 | |
| SCHEMBL14253945 | 0.84 | PIK3CG (0.62) | CAMK2DPIK3CGPIK3CAPIK3CBABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7348335-B2 | Compositions useful as inhibitors of JAK and other protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-03-25 | — | — | US | disclosed |
| US-7348335-B2 | Compositions useful as inhibitors of JAK and other protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-03-25 | — | — | US | disclosed |