Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK10 | P53779 | 5/20 | 0.48 |
| ▸ | BRAF | P15056 | 2/20 | 0.46 |
| ▸ | TNIK | Q9UKE5 | 2/20 | 0.46 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.46 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.45 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | RAF1 | P04049 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | RAD52 | P43351 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 2/20 | 0.44 |
| ▸ | BUB1 | O43683 | 1/20 | 0.43 |
| ▸ | LCK | P06239 | 1/20 | 0.43 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.43 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14254299 | 0.87 | MAPK10 (0.52) | MAPK10TNIKEGFRNTRK1ROCK1 | |
| SCHEMBL14254297 | 0.87 | ROCK1 (0.57) | MAPK10BRAFABCG2MAPTRAF1 | |
| SCHEMBL14254293 | 0.87 | MAPK10 (0.57) | MAPK10MEN1KMT2AEGFRNTRK1 | |
| SCHEMBL14254295 | 0.86 | EGFR (0.50) | MAPK10TNIKCYP1A2TP53MAPT | |
| SCHEMBL14254300 | 0.83 | MAPK10 (0.51) | MAPK10PIK3C3ABCG2MAPTRAF1 | |
| SCHEMBL14254305 | 0.82 | CCNT1 (0.55) | MAPK10BRAFRAF1EGFRROCK1 | |
| SCHEMBL14254312 | 0.81 | PDGFRB (0.47) | MAPK10BRAFTNIKPIK3C3CYP1A1 | |
| SCHEMBL14253945 | 0.81 | PIK3CG (0.62) | CYP1A1CYP1A2CYP1B1TP53POLB | |
| SCHEMBL14254306 | 0.81 | MAPK10 (0.49) | MAPK10TNIKMEN1KMT2ANTRK1 | |
| SCHEMBL14254249 | 0.78 | PIK3CG (0.59) | MEN1KMT2AEGFRLCKPRKCQ |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7348335-B2 | Compositions useful as inhibitors of JAK and other protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-03-25 | — | — | US | disclosed |
| US-7348335-B2 | Compositions useful as inhibitors of JAK and other protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-03-25 | — | — | US | disclosed |