Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK10 | P53779 | 5/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | KIT | P10721 | 1/20 | 0.40 |
| ▸ | AGPAT2 | O15120 | 1/20 | 0.40 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.39 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14254293 | 0.86 | MAPK10 (0.57) | MAPK10MEN1RAB9AKMT2ANPC1 | |
| SCHEMBL14254323 | 0.82 | MAPK10 (0.53) | MAPK10MEN1RAB9AKMT2ANPC1 | |
| SCHEMBL14254297 | 0.81 | ROCK1 (0.57) | MAPK10MEN1RAB9AKMT2ANPC1 | |
| SCHEMBL14254299 | 0.81 | MAPK10 (0.52) | MAPK10NTRK1SYKMAPK9TNIK | |
| SCHEMBL14254294 | 0.81 | MAPK10 (0.48) | MAPK10MEN1KMT2ANTRK1TNIK | |
| SCHEMBL14254295 | 0.81 | EGFR (0.50) | MAPK10MEN1KMT2ADYRK1AALDH1A1 | |
| SCHEMBL14254303 | 0.80 | EGFR (0.55) | MAPK10MEN1KMT2ATGFBR1 | |
| SCHEMBL14254290 | 0.80 | ALDH1A1 (0.48) | MAPK10MEN1RAB9AKMT2ANPC1 | |
| SCHEMBL14253965 | 0.79 | PIK3CG (0.55) | MEN1RAB9AKMT2ANPC1SYK | |
| SCHEMBL14254300 | 0.78 | MAPK10 (0.51) | MAPK10MEN1RAB9AKMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7348335-B2 | Compositions useful as inhibitors of JAK and other protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-03-25 | — | — | US | disclosed |
| US-7348335-B2 | Compositions useful as inhibitors of JAK and other protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-03-25 | — | — | US | disclosed |