Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.54 |
| ▸ | TP53 | P04637 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | THRB | P10828 | 1/20 | 0.54 |
| ▸ | CDC25B | P30305 | 4/20 | 0.53 |
| ▸ | SYK | P43405 | 1/20 | 0.50 |
| ▸ | EGFR | P00533 | 1/20 | 0.49 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.49 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | BRAF | P15056 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14253952 | 0.84 | SYK (0.59) | MAPTTP53LMNATHRBCDC25B | |
| SCHEMBL31240287 | 0.80 | TP53 (0.52) | MAPTTP53LMNATHRBCDC25B | |
| SCHEMBL1519024 | 0.79 | MAPT (0.62) | MAPTTP53LMNATHRBSYK | |
| SCHEMBL14254297 | 0.79 | ROCK1 (0.57) | MAPTSYKEGFRERBB3ROCK1 | |
| SCHEMBL14254299 | 0.79 | MAPK10 (0.52) | SYKEGFRERBB3ROCK1MAPK8 | |
| SCHEMBL14254293 | 0.79 | MAPK10 (0.57) | EGFRROCK1NPC1RAB9AMEN1 | |
| SCHEMBL14254294 | 0.78 | MAPK10 (0.48) | MAPTTP53EGFRROCK1BRAF | |
| SCHEMBL14254295 | 0.78 | EGFR (0.50) | MAPTTP53LMNAEGFRERBB3 | |
| SCHEMBL31240717 | 0.78 | TP53 (0.51) | MAPTTP53LMNATHRBCDC25B | |
| SCHEMBL31240741 | 0.77 | MAPT (0.61) | MAPTTP53LMNATHRBCDC25B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7348335-B2 | Compositions useful as inhibitors of JAK and other protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-03-25 | — | — | US | disclosed |
| US-7348335-B2 | Compositions useful as inhibitors of JAK and other protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-03-25 | — | — | US | disclosed |