Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 4/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | APEX1 | P27695 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TNF | P01375 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4841502 | 1.00 | ALDH1A1 (0.36) | ALDH1A1GAAPOLBMAPK1HSD17B10 | |
| SCHEMBL4845270 | 0.85 | GAA (0.39) | ALDH1A1GAAPOLBMAPK1HSD17B10 | |
| SCHEMBL4841290 | 0.83 | ALDH1A1 (0.44) | ALDH1A1GAAPOLBMAPK1HSD17B10 | |
| SCHEMBL14254608 | 0.83 | ALDH1A1 (0.44) | ALDH1A1GAAPOLBMAPK1HSD17B10 | |
| SCHEMBL4838845 | 0.81 | ALDH1A1 (0.37) | ALDH1A1GAAPOLBMAPK1HSD17B10 | |
| SCHEMBL14254602 | 0.81 | ALDH1A1 (0.37) | ALDH1A1GAAPOLBMAPK1HSD17B10 | |
| SCHEMBL14254634 | 0.78 | TNF (0.42) | ALDH1A1POLBTP53L3MBTL1KMT2A | |
| SCHEMBL4841497 | 0.75 | ALDH1A1 (0.37) | ALDH1A1GAAPOLBMAPK1HSD17B10 | |
| SCHEMBL4838082 | 0.75 | ALDH1A1 (0.37) | ALDH1A1GAAPOLBMAPK1HSD17B10 | |
| SCHEMBL14254630 | 0.74 | POLB (0.33) | ALDH1A1GAAPOLBMAPK1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7342007-B2 | Lactams and uses thereof | ASTRAZENECA AB (SE) | 2008-03-11 | — | — | US | disclosed |
| US-7342007-B2 | Lactams and uses thereof | ASTRAZENECA AB (SE) | 2008-03-11 | — | — | US | disclosed |