Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Duvoglustat. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA known ✓ | P10253 | 6/20 | 1.00 |
| ▸ | GLA known ✓ | P06280 | 4/20 | 1.00 |
| ▸ | FUCA1 | P04066 | 4/20 | 1.00 |
| ▸ | MGAM | O43451 | 4/20 | 1.00 |
| ▸ | GBA2 | Q9HCG7 | 3/20 | 1.00 |
| ▸ | SI | P14410 | 3/20 | 1.00 |
| ▸ | AGL | P35573 | 3/20 | 1.00 |
| ▸ | MEN1 | O00255 | 2/20 | 1.00 |
| ▸ | ALOX15 | P16050 | 2/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 2/20 | 1.00 |
| ▸ | GBA1 | P04062 | 2/20 | 1.00 |
| ▸ | LCT | P09848 | 2/20 | 1.00 |
| ▸ | GBA3 | Q9H227 | 2/20 | 1.00 |
| ▸ | MAN2B1 | O00754 | 1/20 | 1.00 |
| ▸ | MAN2B2 | Q9Y2E5 | 1/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 1.00 |
| ▸ | CYP2C19 | P33261 | 1/20 | 1.00 |
| ▸ | TREH | O43280 | 1/20 | 1.00 |
| ▸ | GANAB | Q14697 | 1/20 | 1.00 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Duvoglustat SCHEMBL13298786 | 1.00 | GAA (1.00) | GAAFUCA1GLAMGAMGBA2 | |
| Duvoglustat SCHEMBL4619759 | 1.00 | GAA (1.00) | GAAFUCA1GLAMGAMGBA2 | |
| Duvoglustat SCHEMBL15896653 | 1.00 | GAA (1.00) | GAAFUCA1GLAMGAMGBA2 | |
| Duvoglustat SCHEMBL10028910 | 1.00 | GAA (1.00) | GAAFUCA1GLAMGAMGBA2 | |
| Duvoglustat SCHEMBL12269503 | 1.00 | GAA (1.00) | GAAFUCA1GLAMGAMGBA2 | |
| Duvoglustat SCHEMBL24518227 | 1.00 | GAA (1.00) | GAAFUCA1GLAMGAMGBA2 | |
| Duvoglustat SCHEMBL2163281 | 1.00 | GAA (1.00) | GAAFUCA1GLAMGAMGBA2 | |
| Duvoglustat SCHEMBL13061461 | 1.00 | GAA (1.00) | GAAFUCA1GLAMGAMGBA2 | |
| Duvoglustat SCHEMBL21104989 | 1.00 | GAA (1.00) | GAAFUCA1GLAMGAMGBA2 | |
| Duvoglustat SCHEMBL9015606 | 1.00 | GAA (1.00) | GAAFUCA1GLAMGAMGBA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 3728 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-122074654-A | Microcapsule type composition for reducing blood sugar and preparation method and application thereof | — | 2026-05-26 | — | — | CN | claimed |
| CN-116410123-B | Preparation method for obtaining 1-deoxynojirimycin from mulberry leaves | 桂林莱茵生物科技股份有限公司 | 2026-05-22 | — | — | CN | claimed |
| EP-4051097-B1 | AUTOMATED AND PRECISE DEVICE FOR DENTAL PLAQUE DETECTION, MONITORING AND REMOVAL | UNIV PENNSYLVANIA (US) | 2026-03-25 | — | — | EP | claimed |
| US-12539322-B2 | Use of mulberry extract for controlling postprandial glucose response | SOCIETE DES PRODUITS NESTLE S.A. (CH) | 2026-02-03 | — | — | US | claimed |
| US-12527830-B2 | Method for treating and preventing ulcerative colitis and method for DAI reduction | BEIJING WEHAND-BIO PHARMACEUTICAL CO., LTD (CN) | 2026-01-20 | — | — | US | claimed |
| EP-4585222-A1 | USE OF MULBERRY EXTRACT IN PREPARATION OF DRUG FOR PREVENTING AND/OR TREATING CHRONIC KIDNEY DISEASE | Beijing Wehand-Bio Pharmaceutical Co., Ltd (CN) | 2025-07-16 | — | — | EP | claimed |
| US-20250213635-A1 | USE OF A COMPOSITION FOR MANAGING POSTPRANDIAL GLUCOSE RESPONSE AND ASSOCIATED DISORDERS | NESTLE SA (CH) | 2025-07-03 | — | — | US | claimed |
| CN-120131746-A | Plant extract composition with synergistic hypoglycemic activity and application thereof | 内蒙古蒙牛乳业（集团）股份有限公司 | 2025-06-13 | — | — | CN | claimed |
| CN-116621830-B | Double-targeting polyhydroxy alkaloid compound and preparation method and application thereof | 中国医学科学院药用植物研究所 | 2025-06-13 | — | — | CN | claimed |
| CN-119454787-B | Extraction method and application of mulberry leaf extract after frost | 烟台市供销社茶业有限公司 | 2025-06-10 | — | — | CN | claimed |
| EP-0353295-A4 | NOVEL AND IMPROVED ANTIBODIES FOR SITE SPECIFIC ATTACHMENT OF COMPOUNDS. | CYTOGEN CORP (US) | 1990-06-26 | — | — | EP | claimed |
| EP-0370205-A2 | Glycosylated polypeptides | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1990-05-30 | — | — | EP | claimed |
| EP-0353295-A1 | NOVEL AND IMPROVED ANTIBODIES FOR SITE SPECIFIC ATTACHMENT OF COMPOUNDS. | CYTOGEN CORP (US) | 1990-02-07 | — | — | EP | claimed |
| WO-1989007114-A1 | NOVEL AND IMPROVED ANTIBODIES FOR SITE SPECIFIC ATTACHMENT OF COMPOUNDS | CYTOGEN CORPORATION (US) | 1989-08-10 | — | — | WO | claimed |
| EP-0318898-A2 | Method for manufacturing 1-deoxymannojirimycin | NIPPON SHINYAKU COMPANY, LIMITED (JP) | 1989-06-07 | — | — | EP | claimed |
| US-4837237-A | Therapy using glucosidase processing inhibitors | FRED HUTCHINSON CANCER RESEARCH CENTER (US) | 1989-06-06 | — | — | US | claimed |
| US-4806650-A | Process for preparing 1-deoxynojirimycin and N-derivatives thereof | BAYER AKTIENGESELLSCHAFT (DE) | 1989-02-21 | — | — | US | claimed |
| EP-0282618-A1 | 1-Deoxynojirimycin as an anti-HIV therapeutic | Vereniging Het Nederlands Kanker Instituut (NL) | 1988-09-21 | — | — | EP | claimed |
| EP-0252962-A1 | REGULATING RETROVIRAL REPLICATION, INFECTION, AND PATHOGENESIS. | HUTCHINSON FRED CANCER RES (US) | 1988-01-20 | — | — | EP | claimed |
| WO-1987003903-A1 | REGULATING RETROVIRAL REPLICATION, INFECTION, AND PATHOGENESIS | FRED HUTCHINSON CANCER RESEARCH CENTER (US) | 1987-07-02 | — | — | WO | claimed |