Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Duvoglustat. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA known ✓ | P10253 | 6/20 | 1.00 |
| ▸ | GLA known ✓ | P06280 | 4/20 | 1.00 |
| ▸ | FUCA1 | P04066 | 4/20 | 1.00 |
| ▸ | MGAM | O43451 | 4/20 | 1.00 |
| ▸ | GBA2 | Q9HCG7 | 3/20 | 1.00 |
| ▸ | SI | P14410 | 3/20 | 1.00 |
| ▸ | AGL | P35573 | 3/20 | 1.00 |
| ▸ | MEN1 | O00255 | 2/20 | 1.00 |
| ▸ | ALOX15 | P16050 | 2/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 2/20 | 1.00 |
| ▸ | GBA1 | P04062 | 2/20 | 1.00 |
| ▸ | LCT | P09848 | 2/20 | 1.00 |
| ▸ | GBA3 | Q9H227 | 2/20 | 1.00 |
| ▸ | MAN2B1 | O00754 | 1/20 | 1.00 |
| ▸ | MAN2B2 | Q9Y2E5 | 1/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 1.00 |
| ▸ | CYP2C19 | P33261 | 1/20 | 1.00 |
| ▸ | TREH | O43280 | 1/20 | 1.00 |
| ▸ | GANAB | Q14697 | 1/20 | 1.00 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Duvoglustat SCHEMBL13298786 | 1.00 | GAA (1.00) | GAAFUCA1GLAMGAMGBA2 | |
| Duvoglustat SCHEMBL4619759 | 1.00 | GAA (1.00) | GAAFUCA1GLAMGAMGBA2 | |
| Duvoglustat SCHEMBL15896653 | 1.00 | GAA (1.00) | GAAFUCA1GLAMGAMGBA2 | |
| Duvoglustat SCHEMBL142573 | 1.00 | GAA (1.00) | GAAFUCA1GLAMGAMGBA2 | |
| Duvoglustat SCHEMBL10028910 | 1.00 | GAA (1.00) | GAAFUCA1GLAMGAMGBA2 | |
| Duvoglustat SCHEMBL12269503 | 1.00 | GAA (1.00) | GAAFUCA1GLAMGAMGBA2 | |
| Duvoglustat SCHEMBL24518227 | 1.00 | GAA (1.00) | GAAFUCA1GLAMGAMGBA2 | |
| Duvoglustat SCHEMBL2163281 | 1.00 | GAA (1.00) | GAAFUCA1GLAMGAMGBA2 | |
| Duvoglustat SCHEMBL13061461 | 1.00 | GAA (1.00) | GAAFUCA1GLAMGAMGBA2 | |
| Duvoglustat SCHEMBL21104989 | 1.00 | GAA (1.00) | GAAFUCA1GLAMGAMGBA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024096497-A1 | COMPOSITION CONTAINING N-NONYLDEOXYNOJIRIMYCIN FOR SUPPRESSION, ALLEVIATION, PALLIATION, OR TREATMENT OF SKIN ITCHING | 차의과학대학교 산학협력단 | 2024-05-10 | — | — | WO | disclosed |
| US-20230365654-A1 | METHOD OF TREATMENT OF FIBROSIS AND WOUND HEALING | CONSEJO NACIONAL DE INVESTIGACIONES CIENTÍFICAS Y TÉCNICAS (AR) | 2023-11-16 | — | — | US | disclosed |
| EP-4225784-A1 | METHOD OF TREATMENT OF FIBROSIS AND WOUND HEALING | Consejo Nacional de Investigaciones Científicas y Técnicas (AR) | 2023-08-16 | — | — | EP | disclosed |
| WO-2023138099-A1 | PREPARATION METHOD FOR MIGLITTOL | 浙江奥翔药业股份有限公司 | 2023-07-27 | — | — | WO | disclosed |
| WO-2022076272-A1 | METHOD OF TREATMENT OF FIBROSIS AND WOUND HEALING | CONSEJO NACIONAL DE INVESTIGACIONES CIENTIFICAS Y TECNICAS (AR) | 2022-04-14 | — | — | WO | disclosed |
| EP-2027137-B1 | IMINO AND AMINO SUGAR PURIFICATION | AMICUS THERAPEUTICS INC (US) | 2015-02-18 | — | — | EP | disclosed |
| CN-101277969-B | Purification of imino and amino sugars | AMICUS THERAPEUTICS INC | 2012-12-19 | — | — | CN | disclosed |
| EP-1534676-B1 | PIPERIDINETRIOL DERIVATIVES AS INHIBITORS OF GLYCOSYLCERAMIDE SYNTHASE | ACTELION PHARMACEUTICALS LTD (CH) | 2012-09-12 | — | — | EP | disclosed |
| US-8071780-B2 | 2-Hydroxymethyl-3,4,5-trihydroxy-1-benzilpiperidine derivatives as inhibitors of glucosylceramide | ACTELION PHARMACEUTICALS LTD. (CH) | 2011-12-06 | — | — | US | disclosed |
| US-8071780-B2 | 2-Hydroxymethyl-3,4,5-trihydroxy-1-benzilpiperidine derivatives as inhibitors of glucosylceramide | ACTELION PHARMACEUTICALS LTD. (CH) | 2011-12-06 | — | — | US | disclosed |
| US-7985760-B2 | Piperidinetriol derivatives as inhibitors of glycosyceramid synthase | ACTELION PHARMACEUTICALS LTD. (CH) | 2011-07-26 | — | — | US | disclosed |
| US-7985760-B2 | Piperidinetriol derivatives as inhibitors of glycosyceramid synthase | ACTELION PHARMACEUTICALS LTD. (CH) | 2011-07-26 | — | — | US | disclosed |
| EP-2027137-A1 | IMINO AND AMINO SUGAR PURIFICATION | Amicus Therapeutics, Inc. (US) | 2009-02-25 | — | — | EP | disclosed |
| CN-101277969-A | Purification of imino and amino sugars | AMICUS THERAPEUTICS INC (US) | 2008-10-01 | — | — | CN | disclosed |
| WO-2008045015-A1 | IMINO AND AMINO SUGAR PURIFICATION | AMICUS THERAPEUTICS, INC. (US) | 2008-04-17 | — | — | WO | disclosed |
| US-20070112028-A1 | 2-Hydroxymethyl-3,4,5-trihydroxy-1-benzilpiperidine derivatives as inhibitors of glucosylceramide | ACTELION PHARMACEUTICALS LTD. | 2007-05-17 | — | — | US | disclosed |
| US-20070112028-A1 | 2-Hydroxymethyl-3,4,5-trihydroxy-1-benzilpiperidine derivatives as inhibitors of glucosylceramide | ACTELION PHARMACEUTICALS LTD. | 2007-05-17 | — | — | US | disclosed |
| US-20060293515-A1 | Imino and amino sugar purification | WILMINGTON TRUST, NATIONAL ASSOCIATION | 2006-12-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070112028-A1 | 2-Hydroxymethyl-3,4,5-trihydroxy-1-benzilpiperidine derivatives as inhibitors of glucosylceramide | GBA1, UGCG, GBA2 | GAA 16/4885GLA 68/4885FUCA1 118/4885 |
| US-20060293515-A1 | Imino and amino sugar purification | MGAM, GCK, GCKR | GAA 227/4885GLA 242/4885FUCA1 2409/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.