Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 2/20 | 0.42 |
| ▸ | MGAM | O43451 | 14/20 | 0.41 |
| ▸ | GAA | P10253 | 14/20 | 0.41 |
| ▸ | SI | P14410 | 14/20 | 0.41 |
| ▸ | MGAM2 | Q2M2H8 | 14/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14259591 | 0.83 | ALDH1A1 (0.42) | GAANPC1ALDH1A1PKMRAB9A | |
| SCHEMBL14259589 | 0.83 | NPC1 (0.49) | ESR1MGAMGAASIMGAM2 | |
| SCHEMBL3140429 | 0.79 | MGAM (0.59) | ESR1MGAMGAASIMGAM2 | |
| SCHEMBL14259590 | 0.74 | NPC1 (0.45) | ESR1MGAMGAASIMGAM2 | |
| SCHEMBL1170892 | 0.68 | MGAM (0.71) | ESR1MGAMGAASIMGAM2 | |
| SCHEMBL7040235 | 0.66 | MGAM (0.52) | MGAMGAASIMGAM2NPC1 | |
| SCHEMBL6056826 | 0.66 | MGAM (0.77) | ESR1MGAMGAASIMGAM2 | |
| SCHEMBL3140425 | 0.65 | ALDH1A1 (0.84) | GAANPC1ALDH1A1PKMRAB9A | |
| SCHEMBL6663139 | 0.65 | MGAM (0.55) | ESR1MGAMGAASIMGAM2 | |
| SCHEMBL15319142 | 0.65 | ESR1 (0.59) | ESR1MGAMGAASIMGAM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080076738-A1 | Phosphonate Analogs Of Hiv Integrase Inhibitor Compounds | GILEAD SCIENCES, INC. | 2008-03-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080076738-A1 | Phosphonate Analogs Of Hiv Integrase Inhibitor Compounds | TYMP, PNP, PIKFYVE | ESR1 2104/4885MGAM 1063/4885GAA 900/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.