Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2 | P10415 | 1/20 | 1.00 |
| ▸ | BCL2L1 | Q07817 | 3/20 | 0.76 |
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CRHBP | P24387 | 2/20 | 0.47 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | SLC16A1 | P53985 | 1/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | SLC10A2 | Q12908 | 1/20 | 0.43 |
| ▸ | SLC10A1 | Q14973 | 1/20 | 0.43 |
| ▸ | SLC10A6 | Q3KNW5 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13242107 | 0.92 | BCL2 (0.85) | BCL2BCL2L1LMNAPOLBALDH1A1 | |
| SCHEMBL29377616 | 0.87 | BCL2L1 (0.77) | BCL2BCL2L1LMNAPOLBALDH1A1 | |
| SCHEMBL4304061 | 0.87 | BCL2L1 (0.77) | BCL2BCL2L1LMNAPOLBALDH1A1 | |
| SCHEMBL14163444 | 0.86 | BCL2L1 (1.00) | BCL2BCL2L1LMNAPOLBALDH1A1 | |
| SCHEMBL13242106 | 0.84 | BCL2 (0.72) | BCL2BCL2L1LMNAPOLBALDH1A1 | |
| SCHEMBL15313811 | 0.83 | BCL2 (0.71) | BCL2BCL2L1LMNAPOLBALDH1A1 | |
| SCHEMBL5150417 | 0.81 | BCL2L1 (0.69) | BCL2BCL2L1LMNAPOLBALDH1A1 | |
| SCHEMBL15313812 | 0.81 | BCL2L1 (0.68) | BCL2BCL2L1LMNAPOLBALDH1A1 | |
| SCHEMBL157069 | 0.78 | BCL2L1 (0.77) | BCL2BCL2L1LMNAPOLBALDH1A1 | |
| SCHEMBL15313855 | 0.76 | BCL2L1 (0.61) | BCL2BCL2L1LMNAPOLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080058322-A1 | Small molecule inhibitors targeted at Bcl-2 | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2008-03-06 | — | — | US | disclosed |
| US-20080058322-A1 | Small molecule inhibitors targeted at Bcl-2 | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2008-03-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080058322-A1 | Small molecule inhibitors targeted at Bcl-2 | BCL2, BCL2L1, BCL2L2 | BCL2 1/4885BCL2L1 2/4885LMNA 3856/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.