Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2L1 | Q07817 | 3/20 | 0.68 |
| ▸ | BCL2 | P10415 | 1/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | SLC16A1 | P53985 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CRHBP | P24387 | 1/20 | 0.44 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.44 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15313811 | 0.85 | BCL2 (0.71) | BCL2L1BCL2ALDH1A1SLC16A1POLB | |
| SCHEMBL15313832 | 0.83 | BCL2L1 (0.63) | BCL2L1BCL2ALDH1A1POLBLMNA | |
| SCHEMBL4304061 | 0.82 | BCL2L1 (0.77) | BCL2L1BCL2ALDH1A1SLC16A1POLB | |
| SCHEMBL29377616 | 0.82 | BCL2L1 (0.77) | BCL2L1BCL2ALDH1A1SLC16A1POLB | |
| SCHEMBL15313800 | 0.82 | BCL2L1 (0.60) | BCL2L1BCL2ALDH1A1SLC16A1POLB | |
| SCHEMBL14163444 | 0.81 | BCL2L1 (1.00) | BCL2L1BCL2ALDH1A1SLC16A1POLB | |
| SCHEMBL14264656 | 0.81 | BCL2 (1.00) | BCL2L1BCL2ALDH1A1SLC16A1POLB | |
| SCHEMBL5150417 | 0.81 | BCL2L1 (0.69) | BCL2L1BCL2ALDH1A1SLC16A1POLB | |
| SCHEMBL13242107 | 0.80 | BCL2 (0.85) | BCL2L1BCL2ALDH1A1SLC16A1POLB | |
| SCHEMBL15313785 | 0.80 | BCL2 (0.67) | BCL2L1BCL2ALDH1A1SLC16A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |