Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 20/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 17/20 | 0.59 |
| ▸ | OPRK1 | P41145 | 6/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 12/20 | 0.56 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL471396 | 0.80 | OPRD1 (0.63) | OPRD1KCNH2OPRK1CYP2D6OPRM1 | |
| SCHEMBL471393 | 0.78 | OPRD1 (0.66) | OPRD1KCNH2OPRK1CYP2D6OPRM1 | |
| SCHEMBL10258565 | 0.77 | OPRD1 (0.62) | OPRD1KCNH2OPRK1CYP2D6OPRM1 | |
| SCHEMBL471369 | 0.77 | OPRD1 (0.68) | OPRD1KCNH2OPRK1CYP2D6OPRM1 | |
| SCHEMBL471371 | 0.77 | OPRD1 (0.64) | OPRD1KCNH2OPRK1CYP2D6OPRM1 | |
| SCHEMBL471378 | 0.77 | OPRD1 (0.64) | OPRD1KCNH2OPRK1CYP2D6OPRM1 | |
| SCHEMBL10258858 | 0.76 | OPRD1 (0.72) | OPRD1KCNH2OPRK1CYP2D6OPRM1 | |
| SCHEMBL471328 | 0.75 | OPRD1 (1.00) | OPRD1KCNH2OPRK1CYP2D6OPRM1 | |
| SCHEMBL467151 | 0.75 | OPRD1 (1.00) | OPRD1KCNH2OPRK1CYP2D6OPRM1 | |
| SCHEMBL467343 | 0.74 | OPRD1 (0.66) | OPRD1KCNH2OPRK1CYP2D6OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7338962-B2 | Spirocyclic heterocyclic derivatives and methods of their use | ADOLOR CORPORATION (US) | 2008-03-04 | — | — | US | disclosed |
| US-7338962-B2 | Spirocyclic heterocyclic derivatives and methods of their use | ADOLOR CORPORATION (US) | 2008-03-04 | — | — | US | disclosed |