Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | PPARG | P37231 | 2/20 | 0.38 |
| ▸ | PPARA | Q07869 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.37 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14265709 | 0.94 | MAPT (0.43) | MAPTLMNARXFP1TSHRNR1H4 | |
| SCHEMBL5107495 | 0.93 | MAPT (0.46) | MAPTLMNARXFP1TSHRNR1H4 | |
| SCHEMBL5140361 | 0.93 | MAPT (0.46) | MAPTLMNARXFP1TSHRNR1H4 | |
| SCHEMBL5107504 | 0.93 | MAPT (0.46) | MAPTLMNARXFP1TSHRNR1H4 | |
| SCHEMBL5107687 | 0.83 | KMT2A (0.42) | MAPTLMNARXFP1TSHRKMT2A | |
| SCHEMBL5113624 | 0.83 | KMT2A (0.42) | MAPTLMNARXFP1TSHRKMT2A | |
| SCHEMBL5107694 | 0.83 | KMT2A (0.42) | MAPTLMNARXFP1TSHRKMT2A | |
| SCHEMBL14265701 | 0.82 | MEN1 (0.52) | MAPTTSHRKMT2APOLBPPARG | |
| SCHEMBL7249198 | 0.81 | PPARA (0.55) | MAPTRXFP1NR1H4KMT2APOLB | |
| SCHEMBL7251593 | 0.81 | PPARA (0.55) | MAPTRXFP1NR1H4KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7348426-B1 | Substituted bicyclic heterocycles, process for their preparation and their use as antiobesity and hypocholesterolemic agents | DR. REDDY'S LABORATIES LIMITED (IN) | 2008-03-25 | — | — | US | disclosed |