Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 17/20 | 1.00 |
| ▸ | MT-CO2 | P00403 | 3/20 | 0.78 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.78 |
| ▸ | CA12 | O43570 | 1/20 | 0.78 |
| ▸ | CA1 | P00915 | 1/20 | 0.78 |
| ▸ | CA2 | P00918 | 1/20 | 0.78 |
| ▸ | LMNA | P02545 | 1/20 | 0.78 |
| ▸ | CA3 | P07451 | 1/20 | 0.78 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.78 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.78 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.78 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.78 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.78 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.78 |
| ▸ | CA4 | P22748 | 1/20 | 0.78 |
| ▸ | CA6 | P23280 | 1/20 | 0.78 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.78 |
| ▸ | PDE4A | P27815 | 1/20 | 0.78 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.78 |
| ▸ | CA5A | P35218 | 1/20 | 0.78 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4800858 | 1.00 | PTGS2 (1.00) | PTGS2MT-CO2PTGS1CA12CA1 | |
| SCHEMBL6169904 | 0.89 | PTGS2 (0.81) | PTGS2MT-CO2PTGS1CA12CA1 | |
| SCHEMBL6170420 | 0.89 | PTGS2 (0.82) | PTGS2MT-CO2PTGS1CA12CA1 | |
| Valdecoxib SCHEMBL3853130 | 0.87 | PTGS2 (1.00) | PTGS2MT-CO2PTGS1CA12CA1 | |
| SCHEMBL4587749 | 0.87 | PTGS2 (1.00) | PTGS2MT-CO2PTGS1CA12CA1 | |
| SCHEMBL6167941 | 0.87 | PTGS2 (1.00) | PTGS2MT-CO2PTGS1CA12CA1 | |
| Valdecoxib SCHEMBL3356 | 0.87 | PTGS2 (1.00) | PTGS2MT-CO2PTGS1CA12CA1 | |
| SCHEMBL6168344 | 0.87 | PTGS2 (1.00) | PTGS2MT-CO2PTGS1CA12CA1 | |
| SCHEMBL4888365 | 0.86 | PTGS2 (0.78) | PTGS2MT-CO2PTGS1CA12CA1 | |
| Valdecoxib SCHEMBL5999213 | 0.86 | PTGS2 (0.97) | PTGS2MT-CO2PTGS1CA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7329401-B2 | Cyclooxygenase-2 selective agents useful as imaging probes and related methods | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2008-02-12 | — | — | US | disclosed |
| US-20070286801-A1 | CYCLOOXYGENASE-2 SELECTIVE AGENTS USEFUL AS IMAGING PROBES AND RELATED METHODS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2007-12-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070286801-A1 | CYCLOOXYGENASE-2 SELECTIVE AGENTS USEFUL AS IMAGING PROBES AND RELATED METHODS | PTGS2, PTGES2, PTGER2 | PTGS2 1/4885MT-CO2 520/4885PTGS1 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.