Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | RORC | P51449 | 4/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3561065 | 1.00 | REN (0.36) | RENTSHRMAPTNPC1RAB9A | |
| SCHEMBL2925320 | 1.00 | REN (0.36) | RENTSHRMAPTNPC1RAB9A | |
| SCHEMBL1040158 | 0.96 | REN (0.36) | RENTSHRMAPTNPC1RAB9A | |
| SCHEMBL2920516 | 0.95 | REN (0.36) | RENTSHRMAPTNPC1RAB9A | |
| SCHEMBL2919734 | 0.95 | TSHR (0.35) | RENTSHRMAPTTHRBKMT2A | |
| SCHEMBL8455576 | 0.94 | REN (0.35) | RENMAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2923638 | 0.94 | REN (0.35) | RENMAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL1038117 | 0.94 | REN (0.34) | RENTSHRMAPTNPC1RAB9A | |
| SCHEMBL2917460 | 0.94 | REN (0.35) | RENMAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL3466476 | 0.94 | REN (0.35) | RENMAPTNPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1897879-A2 | 2,4,5 substituted piperidines as renin inhibitors | Speedel Experimenta AG (CH) | 2008-03-12 | — | — | EP | disclosed |