Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | KDM1A | O60341 | 3/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.43 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6393580 | 0.83 | KDM1A (0.49) | TSHRALOX15KDM1AATMPDK2 | |
| SCHEMBL14272804 | 0.79 | KDM1A (0.46) | TSHRALOX15KDM1AATMPDK2 | |
| SCHEMBL14272807 | 0.79 | KDM1A (0.57) | TSHRALOX15KDM1AATMGPR119 | |
| SCHEMBL6397393 | 0.78 | KDM1A (0.49) | TSHRALOX15KDM1AATMPDK2 | |
| SCHEMBL14272818 | 0.78 | KDM1A (0.49) | TSHRALOX15KDM1AATMPDK2 | |
| SCHEMBL14272806 | 0.78 | KDM1A (0.49) | TSHRALOX15KDM1AATMPDK2 | |
| SCHEMBL31645476 | 0.78 | KDM1A (0.45) | TSHRALOX15KDM1AATMPDK2 | |
| SCHEMBL21940602 | 0.76 | KDM1A (0.45) | TSHRALOX15KDM1AATMPDK2 | |
| SCHEMBL14300921 | 0.76 | ATM (0.46) | TSHRALOX15KDM1AATMPDK2 | |
| SCHEMBL6959970 | 0.75 | KDM1A (0.52) | TSHRALOX15KDM1AATMPDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7329673-B2 | Acylated spiropiperidine derivatives as melanocortin-4 receptor agonists | MERCK & CO., INC. (US) | 2008-02-12 | — | — | US | disclosed |
| US-7329673-B2 | Acylated spiropiperidine derivatives as melanocortin-4 receptor agonists | MERCK & CO., INC. (US) | 2008-02-12 | — | — | US | disclosed |