Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 4/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 9/20 | 0.42 |
| ▸ | SRC | P12931 | 5/20 | 0.38 |
| ▸ | GSK3A | P49840 | 8/20 | 0.38 |
| ▸ | SYK | P43405 | 4/20 | 0.37 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.37 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.37 |
| ▸ | RAF1 | P04049 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14276236 | 0.91 | BRAF (0.44) | BRAFMAPK14SRCGSK3ASYK | |
| SCHEMBL5681259 | 0.89 | BRAF (0.43) | BRAFMAPK14SRCGSK3ASYK | |
| SCHEMBL14276166 | 0.89 | MAPK14 (0.42) | BRAFMAPK14SRCGSK3ASYK | |
| SCHEMBL14276248 | 0.89 | BRAF (0.38) | BRAFMAPK14GSK3A | |
| SCHEMBL5114323 | 0.85 | CDK1 (0.38) | BRAFMAPK14SRCGSK3A | |
| SCHEMBL5681284 | 0.85 | GSK3A (0.46) | MAPK14SRCGSK3ASYK | |
| SCHEMBL14276242 | 0.85 | BRAF (0.43) | BRAFMAPK14SRCGSK3A | |
| SCHEMBL14276165 | 0.85 | MAPK14 (0.44) | MAPK14SRCGSK3ASYK | |
| SCHEMBL14276178 | 0.85 | BRAF (0.51) | BRAFMAPK14SRCGSK3ASYK | |
| SCHEMBL14276240 | 0.84 | BRAF (0.46) | BRAFMAPK14SRCGSK3ASYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7335657-B2 | Cytokine inhibitors | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2008-02-26 | — | — | US | disclosed |
| US-7335657-B2 | Cytokine inhibitors | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2008-02-26 | — | — | US | disclosed |