Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 7/20 | 0.42 |
| ▸ | GSK3A | P49840 | 13/20 | 0.42 |
| ▸ | BRAF | P15056 | 3/20 | 0.39 |
| ▸ | SRC | P12931 | 3/20 | 0.36 |
| ▸ | SYK | P43405 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14276165 | 0.91 | MAPK14 (0.44) | MAPK14GSK3ASRCSYK | |
| SCHEMBL14276237 | 0.89 | BRAF (0.46) | MAPK14GSK3ABRAFSRCSYK | |
| SCHEMBL5115049 | 0.88 | GSK3A (0.45) | MAPK14GSK3ASRCSYK | |
| SCHEMBL14276192 | 0.87 | MAPK14 (0.45) | MAPK14GSK3ASRCSYK | |
| SCHEMBL5682608 | 0.86 | MAPK14 (0.57) | MAPK14GSK3ABRAFSRCSYK | |
| SCHEMBL13688789 | 0.86 | GSK3A (0.43) | MAPK14GSK3ABRAFSRCSYK | |
| SCHEMBL5685202 | 0.85 | BRAF (0.47) | MAPK14GSK3ABRAF | |
| SCHEMBL14276231 | 0.85 | GSK3A (0.46) | MAPK14GSK3ASRCSYK | |
| SCHEMBL5681284 | 0.85 | GSK3A (0.46) | MAPK14GSK3ASRCSYK | |
| SCHEMBL14276242 | 0.85 | BRAF (0.43) | MAPK14GSK3ABRAFSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7335657-B2 | Cytokine inhibitors | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2008-02-26 | — | — | US | disclosed |
| US-7335657-B2 | Cytokine inhibitors | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2008-02-26 | — | — | US | disclosed |