Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC9A1 | P19634 | 19/20 | 1.00 |
| ▸ | SLC9A2 | Q9UBY0 | 1/20 | 0.50 |
| ▸ | CDC7 | O00311 | 1/20 | 0.45 |
| ▸ | PLK4 | O00444 | 1/20 | 0.45 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.45 |
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.45 |
| ▸ | PAK4 | O96013 | 1/20 | 0.45 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.45 |
| ▸ | EGFR | P00533 | 1/20 | 0.45 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.45 |
| ▸ | PRKCG | P05129 | 1/20 | 0.45 |
| ▸ | INSR | P06213 | 1/20 | 0.45 |
| ▸ | LCK | P06239 | 1/20 | 0.45 |
| ▸ | FYN | P06241 | 1/20 | 0.45 |
| ▸ | CDK1 | P06493 | 1/20 | 0.45 |
| ▸ | LYN | P07948 | 1/20 | 0.45 |
| ▸ | MET | P08581 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14276728 | 0.91 | SLC9A1 (1.00) | SLC9A1SLC9A2 | |
| SCHEMBL14276734 | 0.89 | SLC9A1 (1.00) | SLC9A1SLC9A2STK3 | |
| SCHEMBL14276730 | 0.89 | SLC9A1 (1.00) | SLC9A1SLC9A2 | |
| SCHEMBL14276725 | 0.89 | SLC9A1 (0.84) | SLC9A1SLC9A2 | |
| SCHEMBL14276729 | 0.88 | SLC9A1 (1.00) | SLC9A1SLC9A2 | |
| SCHEMBL14276812 | 0.88 | SLC9A1 (1.00) | SLC9A1SLC9A2STK3 | |
| SCHEMBL14276820 | 0.88 | SLC9A1 (0.78) | SLC9A1SLC9A2 | |
| SCHEMBL14276825 | 0.87 | SLC9A1 (0.81) | SLC9A1SLC9A2 | |
| SCHEMBL14276818 | 0.87 | SLC9A1 (0.78) | SLC9A1SLC9A2 | |
| SCHEMBL14276731 | 0.86 | SLC9A1 (1.00) | SLC9A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7326705-B2 | Heterocyclic sodium/proton exchange inhibitors and method | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-02-05 | — | — | US | disclosed |