Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC9A1 | P19634 | 19/20 | 0.70 |
| ▸ | SLC9A2 | Q9UBY0 | 1/20 | 0.67 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14276855 | 0.92 | SLC9A1 (0.67) | SLC9A1SLC9A2LRRK2 | |
| SCHEMBL14276833 | 0.91 | SLC9A1 (0.73) | SLC9A1SLC9A2 | |
| SCHEMBL14276830 | 0.87 | SLC9A1 (0.80) | SLC9A1SLC9A2 | |
| SCHEMBL14276872 | 0.87 | SLC9A1 (0.55) | SLC9A1SLC9A2LRRK2 | |
| SCHEMBL14276750 | 0.87 | SLC9A1 (0.78) | SLC9A1SLC9A2LRRK2 | |
| SCHEMBL14276832 | 0.86 | SLC9A1 (0.77) | SLC9A1SLC9A2LRRK2 | |
| SCHEMBL14276829 | 0.85 | SLC9A1 (0.71) | SLC9A1SLC9A2 | |
| SCHEMBL14276835 | 0.83 | SLC9A1 (0.85) | SLC9A1SLC9A2 | |
| SCHEMBL14276836 | 0.83 | SLC9A1 (0.69) | SLC9A1SLC9A2 | |
| SCHEMBL14276752 | 0.83 | SLC9A1 (1.00) | SLC9A1SLC9A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7326705-B2 | Heterocyclic sodium/proton exchange inhibitors and method | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-02-05 | — | — | US | disclosed |
| US-7326705-B2 | Heterocyclic sodium/proton exchange inhibitors and method | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-02-05 | — | — | US | disclosed |