Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 18/20 | 0.66 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.66 |
| ▸ | HSD11B2 | P80365 | 9/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14277197 | 1.00 | HSD11B1 (0.66) | HSD11B1HSD17B1HSD11B2POLB | |
| SCHEMBL14277194 | 1.00 | HSD11B1 (0.66) | HSD11B1HSD17B1HSD11B2POLB | |
| SCHEMBL14277193 | 0.99 | HSD11B1 (0.63) | HSD11B1HSD17B1HSD11B2POLB | |
| SCHEMBL5253884 | 0.94 | HSD11B1 (0.57) | HSD11B1HSD17B1HSD11B2POLB | |
| Trifluoroacetic Acid SCHEMBL5104740 | 0.89 | HSD11B1 (0.53) | HSD11B1HSD17B1HSD11B2 | |
| Trifluoroacetic Acid SCHEMBL5098023 | 0.89 | HSD11B1 (0.53) | HSD11B1HSD17B1HSD11B2 | |
| Trifluoroacetic Acid SCHEMBL5095893 | 0.89 | HSD11B1 (0.53) | HSD11B1HSD17B1HSD11B2 | |
| SCHEMBL14382298 | 0.88 | HSD11B1 (0.72) | HSD11B1HSD17B1HSD11B2POLB | |
| Trifluoroacetic Acid SCHEMBL5098031 | 0.87 | HSD11B1 (0.51) | HSD11B1HSD17B1HSD11B2 | |
| SCHEMBL5104769 | 0.86 | HSD11B1 (0.59) | HSD11B1HSD17B1HSD11B2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7329683-B2 | 11-β-hydroxysteroid dehydrogenase 1 inhibitors useful for the treatment of diabetes, obesity and dyslipidemia | MERCK & CO., INC. (US) | 2008-02-12 | — | — | US | disclosed |
| US-7329683-B2 | 11-β-hydroxysteroid dehydrogenase 1 inhibitors useful for the treatment of diabetes, obesity and dyslipidemia | MERCK & CO., INC. (US) | 2008-02-12 | — | — | US | disclosed |