SCHEMBL14277451

SCHEMBL14277451

CC(C)(C)OC(=O)NC(C)(C)C(=O)N1CC(c2cc(Cl)ccc2F)=CC1c1cccc(O)c1

nearest known ligand 0.61

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
KIF11 P52732 20/20 0.61
KCNH2 Q12809 15/20 0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4067960 0.86 KIF11 (0.47) KIF11KCNH2
SCHEMBL4064573 0.84 KIF11 (0.70) KIF11KCNH2
SCHEMBL4067473 0.84 KIF11 (0.70) KIF11KCNH2
SCHEMBL4071719 0.78 KIF11 (0.70) KIF11KCNH2
SCHEMBL13655902 0.78 KIF11 (0.70) KIF11KCNH2
SCHEMBL4978603 0.78 KIF11 (0.70) KIF11KCNH2
SCHEMBL4059157 0.77 KIF11 (1.00) KIF11KCNH2
SCHEMBL14277494 0.77 KIF11 (1.00) KIF11KCNH2
SCHEMBL4067206 0.76 KIF11 (0.86) KIF11KCNH2
SCHEMBL4060443 0.76 KIF11 (0.70) KIF11KCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7329762-B2 Prodrugs of mitotic kinesin inhibitors MERCK & CO., INC. (US) 2008-02-12 US disclosed